Physiology Based Pharmacokinetic (Pbpk) Model in Paediatric Drug Development

D.M. Ravichand, G Naveen choudary,

doi:10.52783/jchr.v13.i6.1878

Published: Dec 6, 2023

Keywords:

PBPK model, paediatrics, drug development

D.M. Ravichand, G Naveen choudary,

Abstract

Purpose

Physiologically based pharmacokinetic (PBPK) modelling, a mathematical modelling approach which uses a pharmacokinetic model to mimic human physiology to predict drug concentration–time profiles, has been used for the discover and development of drugs in various fields, including oncology, since 2000. There have been a few general review articles on the utilization of PBPK in the development of oncology drugs, but these do not include an evaluation of model prediction accuracy. There have been a few general review articles on the utilization of PBPK in the development of oncology drugs, but these do not include an evaluation of model prediction accuracy.

Issue

Vol. 13 No. 6 (2023)

Section

Articles

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