A Case report on Hand -foot- syndrome due to Capecitabine Adverse drug reaction.

Abstract

Capecitabine is a prodrug of 5-Fluorouracil and is commonly used to treat breast, colon and gastric cancer. The drug is also known to cause Hand and Foot Syndrome (HFS). Which can be life threatening for some patients. The comorbidities such as old Age, Hypertension and Asthma could increase the risk of HFS in the patient and it is necessary to look for any signs and symptoms of HFS in such patients. This is a case report of a 65-year-old woman who is diagnosed with colorectal cancer and prescribed with Oxaliplatin and Capecitabine as primary treatment for the same. She has experienced HFS during treatment which has been described in detail in this case report. Discussion of various possible cause of HFS, changes in lab parameters and further progression of disease into Steven-Jonsen Syndrome is also discussed.