A Multicentre Observational Study: Building a Bridge to CKD Prevention in Diabetic Nephropathy Through Antioxidant Strategies

Abstract

Introduction:

The objective of this study was to examine the impact of antioxidant therapy on renal and glycaemic indicators in a cohort of 150 patients diagnosed with diabetic nephropathy. The researchers recruited participants who had been diagnosed with both type 1 and type 2 diabetes. This study aimed to explore the potential benefits of antioxidants in the management of renal disease and the control of blood glucose levels. The patients were categorized based on their age, gender, body mass index (BMI), and type of diabetes to examine differences in their treatment response. The noteworthy discoveries encompass substantial decreases in microalbuminuria and HbA1c levels within the cohort subjected to vitamin treatment, suggesting enhanced kidney function and glycaemic regulation. Furthermore, the patients in the vitamin group observed a significant decrease in their serum creatinine levels, indicating the potential for improved kidney function. In addition, the group receiving antioxidants showed noteworthy enhancements in both their fasting and post-prandial blood glucose levels. The study emphasized the importance of early detection and intervention in diabetic kidney disease, especially in persons with type 2 diabetes, to prevent the development of end-stage renal disease. Moreover, the research findings suggest that antioxidant supplementation could play a crucial role in the treatment of kidney problems linked to diabetes.