Effect of GinLemClo Lozenges (Ginger, Lemongrass and Clove) on Concentration of TLR2 and TLR4 Proteins Expression in Recurrent Aphthous Stomatitis (SAR) in Young Adult Female

Abstract

Introduction: The prevalence of SAR ranges from 15-25% of the population, with the prevalence in young age groups in Indonesia ranging from 35-45%. No study has evaluated the combination formula of ginger, lemongrass, and cloves in relation to a decrease in serum TLR2 and TLR4 protein concentrations.

Objectives: This study aimed to examine the effect of the three herbal formulas in the form of lozenges GinLemClo (ginger, lemongrass, clove). Methods: The study design was a Randomized Control Trial (RCT) pretest-posttest group on 52 subjects with SAR.

Methods: This study was divided 14 subjects receiving GinLemClo lozenges 700 mg twice a day, 14 subjects receiving 500 mg vitamin C lozenges, and 14 subjects receiving vitamin C lozenges combined with for 7 days to evaluate the changes in serum TLR2 and TLR4 levels. After one week of administration of GinLemClo lozenges 700 mg twice a day, all subjects had complete closure of the SAR lesions.

Results: The administration of GinLemClo lozenges had a significant effect on decreasing the concentrations of serum TLR2 (p<0.001) and TLR4 (p0.003), as well as vitamin C lozenges TLR2 (p0.005) and TLR4 (p0.004); vitamin C lozenges combined with GinLemClo TLR2 (p0.001) and TLR4 (p<0.001).

Conclusions: The use of GinLemClo lozenges, vitamin C, and their combination significantly decreased serum TLR2 and TLR4 protein concentrations in young adult female SAR patients