Serum Visfatin Levels are Positively Linked with Dietary Carbohydrate and Polyunsaturated Fatty Acid Consumption in type 2 Diabetic Individuals

Abstract

Introduction: Diabetes mellitus is characterized mainly by hyperglycaemia occurring due to defects in insulin secretion, insulin action, or both. According to the International Diabetes Federation (IDF), 463 million people globally have been diagnosed with diabetes in 2019 and the figure is expected to rise to 700 million by 2040. Aims and Objective: To correlate adipokines (Visfatin and Adeponectin), oxidative stress levels, anthropometric and clinical parameters in T2DM patients.

Methods and materials: This case control study was conducted at Index Medical College, Hospital and Research Centre Indore MP, India. Either sex, age between 35 to 65 years patients with or without diabetes who reported in OPD of Medicine department during study period was enrolled in study.

Result: shows that the serum levels of adipokines (Visfatin) level were significantly higher in the case group in comparison to control group (P<0.05). But adiponectin level was significantly lower in the case group in comparison to control group (P<0.05).

Conclusion: Adiponectin negative significant associated with fasting plasma glucose, insulin level, HbA1c, Total Cholesterol, Triglycerides, urea, creatinine, AST and ALT; but it was positive significant correlated with HDL and Albumin. Visfatin negatively significant associated with Catalase, Superoxide dismutase (SOD) and Glutathine reductase; while it was positively significant correlated with MDA.