Association between digit ratio (2D: 4D) and coronary artery disease

Abstract

Background- There is several predisposing risk factors of getting heart diseases. Coronary artery disease is sexually dimorphic, being more prevalent in males. The ratio of second and fourth digit (2D: 4D) is a sexually dimorphic biometric marker. The association between 2D: 4D and cardiac disorders have been reported. The aim of the study is to investigate whether 2D: 4D can be used as a tool for early diagnosis of coronary artery disease.

Method-This study includes 210 individuals, out of which 127 were males and 83 were females. Lengths of 2nd and 4th finger were measured for both hands using vernier calipers. Student t test was used to find the difference of 2D: 4D among different groups.

Result-In the present study, there was a significant difference in males with CAD and without CAD. 2D: 4D ratio was higher in both the hands in males with CAD as compared to patients without CAD. No such difference was seen in females. Females have higher ratio then males for right hand in patients without CAD.

Conclusion-There is an association between high 2D: 4D ratio and coronary artery disease in males but there is no association seen in females.