Genetic Association of Visfatin Gene G-948T Polymorphism with Biochemical Parameters and Oxidative Stress Markers in Type 2 Diabetic Patients

Abstract

Visfatin are bioactive molecules that control a wide range of physiological processes, including insulin action, the inflammatory process, and vascular homeostasis. The aim of this study is to ascertain the relationship between serum visfatin levels and other biochemical markers. More than 300 people from Outpatient Department of Medicine of Santosh Medical College took part in the study. Out of the 300 participants chosen, 150 had type 2 diabetes, while the remaining 150 acted as the control group. All subjects' lipid profiles, fasting plasma glucose, glycosylated hemoglobin, and visfatin serum concentrations were examined. The outcome showed that the visfatin serum concentration were higher in subjects with type 2 diabetes mellitus than the control groups. Visfatin was found to be correlated with some biochemical parameters. From the obtained results we concluded that the assessment of visfatin levels and their relation to some metabolic parameters can help to identify subjects who are more susceptible to cardiovascular disease.