Phenotypic Detection of Drug Resistance among Acinetobacter Species Isolated from ICUs in a Tertiary Care Hospital

Abstract

Introduction: The spread of Acinetobacter infections and its drug resistance become emergence in past few years, resistant to majority groups of antibiotics is a great concern. Acinetobacter species are frequently associated with healthcare associated infections. Treatment and management of drug-resistant Acinetobacter infections is a big challenge for clinicians and microbiologists.

Methodology: A total 50 Acinetobacter species were collected and isolated from ICU patients were included in this study. The isolates were subjected for Antibiotic sensitivity testing and phenotypic detection of drug resistance (ESBL, CarbaNP test, Amp C test).

Results: Among 50 isolates 47 were Acinetobacter baumanii, 2 were Acintobacter lwofii, 1 Acinetobacter calcaucatius. In this study 7(14%) of the isolates were ESBL producers and 19(38%) of the isolates showed carbapenemase production, 14(28%) of the isolates showed Amp C production.

Conclusion: Acinetobacter infections are often associated with hospital acquired infections especially in critical care units. Speciation, In-vitro susceptibility testing and detection of drug resistance plays a crucial role to choose an appropriate antibiotic for treatment and management of case.