Enhanced Targeted Therapy for Breast Cancer: Magnetic Nanoparticles Loaded with Anti-Neoplastic Agents"
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Abstract
Background: The treatment of breast cancer requires specific therapeutic approaches that can increase effectiveness while reducing the harmful effects on the whole body. Magnetic nanoparticles containing anti-neoplastic drugs present a promising approach for accurate drug administration.
Methods: The synthesis of MNPs (magnetic nanoparticles) was carried out utilising a co-precipitation approach. The resulting nanoparticles were then analysed to determine their size, shape, and surface charge. The process of nanoprecipitation was employed to effectively load anti-neoplastic medicines onto MNPs (magnetic nanoparticles). An evaluation was conducted to determine the physicochemical characteristics and efficiency of drug loading. The cytotoxicity of breast cancer cells was assessed using in vitro research, whereas in vivo experiments examined tumour targeting and therapeutic efficacy using xenograft models.
Results: The artificially produced MNPs displayed an average size of 20 ± 5 nm, possessing a spherical shape and a surface charge of -25 mV. The drug loading efficiency was very high for both Drug A (75 ± 3%) and Drug B (68 ± 5%). Experiments conducted in a controlled laboratory environment showed that the survival of MCF-7 breast cancer cells reduced as the concentration of nanoparticles increased, indicating a dose-dependent cytotoxic effect. Experiments conducted in living organisms demonstrated increased buildup of tumours and substantial regression of the tumours.
Conclusion: Magnetic nanoparticles containing anti-neoplastic drugs have advantageous properties for precise breast cancer treatment. Their high drug-loading capacity, ability to kill cancer cells, and improved ability to target tumours highlight their promise as effective drug delivery vehicles.