Effect Of Pterostilbene On The Kidney Of C57BL/6J Mice With High Fat-Diet Induced Oxidative Stress

Abstract

Pterocarpus marsupium has been used for many years in the treatment of diabetes mellitus. Pterostilbene (PTS) was found to be one of the active constituents in the extracts of the heartwood of Pterocarpus marsupium.  Pterostilbene is a useful bioactive compound in preventing type 1 diabetes, insulin resistance and type 2 diabetes in animal models. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, exhibits many of the same physiologic and pharmacological activities as curcumin and in some systems may exert greater antioxidant activity than curcumin. The present study evaluated the protective effect of THC and PTS on high fat diet (HFD) induced diabetic mice. C57BL/6J mice were segregated in two groups, one fed standard diet (NC) and the other fed HFD for 16 weeks. Mice were fed continuously with high fat diet for 16 weeks and subjected to intragastric administration of THC (80 mg/kg body weight), PTS (40 mg/kg body weight) 9 to 16 weeks. At the end of the treatment nephritic markers, lipid peroxidation product, antioxidant examination was carried out to assess the efficacy of the treatment. HFD fed mice showed increased plasma glucose, insulin, altered nephritic markers, antioxidant. Oral Treatment with THC and PTS showed near normalized levels of plasma glucose, lipid peroxidation product, antioxidants, improved insulin and reduced kidney damage. THC administration showed more effective than PTS.