Evaluation of 8-Hydroxy Deoxyguanosine Levels, as a Marker of Oxidative Stress in Chronic Gingivitis and Chronic Periodontitis Individuals During the Course of Phase-I Periodontal Therapy in Comparison with Periodontally Healthy Individuals

Abstract

Aim:  The aim was to evaluate the levels of 8-Hydroxy deoxyguanosine levels, as a marker of oxidative stress in Chronic Gingivitis and Chronic Periodontitis individuals during the course of Phase-I periodontal therapy in comparison with Periodontally healthy Individuals.

Materials And Method:  All the individuals were divided into 3 groups each including 16 subjects. Group 1 included healthy subjects and group 3 and 4 included subjects with chronic gingivitis and chronic periodontitis respectively. Saliva samples were collected and the 8-OHdG levels were assessed.

Results: The levels reduced to 1.59±0.50 in chronic periodontitis group one month after scaling and root planing. A statistically non-significant value of 0.09 was recorded. The levels in chronic gingivitis group were 1.20±0.89.

Conclusion: From the above study it can be concluded that 8-OHdG is an important biomarker of oxidative stress and is increased in patients with chronic gingivitis and chronic periodontitis.