Synthesis, Characterization, and Antibacterial Property of Strontium Substituted Hydroxyapatite Nanoparticles

Abstract

Nanotechnology has emerged as a transformative force in medical disciplines, presenting innovative opportunities for enhancing therapeutic outcomes. This study delves into the integration of strontium-substituted hydroxyapatite nanoparticles (SrHA) into orthodontic composites, exploring their antimicrobial properties. Strontium, recognized for its roles in promoting cell proliferation and inhibiting bone resorption, is introduced into hydroxyapatite—a critical bioactive material in dentistry. The synthesis employs a chemical precipitation method, resulting in Sr-enriched HA nanoparticles with precise stoichiometry. Characterization techniques, including X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy, provide comprehensive insights into the resulting orthodontic composite.

Antimicrobial testing is conducted on SrHA-infused composites at concentrations of 0.5% and 1.0%, targeting S. aureus, S. mutans, and E. coli. The disc agar diffusion test reveals significant antimicrobial efficacy, with inhibition zones measuring 26-30 mm. Statistical analysis confirms concentration-dependent effectiveness against the tested bacteria.

The study underscores the potential of SrHA-infused composites in preventing white spot lesions, emphasizing their antimicrobial effects against S. mutans. Scanning electron microscopy exposes morphological shifts, indicating strontium-induced changes in particle size and shape. Energy-dispersive X-ray spectroscopy confirms strontium substitution within the nanoparticles.

In conclusion, the incorporation of SrHA nanoparticles into orthodontic composites showcases promising antimicrobial properties, hinting at their potential for preventing bacterial colonization and plaque formation. This research provides valuable insights into the synthesis, characterization, and antimicrobial efficacy of SrHA-infused orthodontic composites, contributing significantly to the ongoing advancement of dental biomaterials.