Dental Implant Failure in Osteoporotic Females on Bisphosphonate Therapy: A Systematic Review

Abstract

Objective: The goal of this systematic review was to systematically evaluate the relationship between bisphosphonate therapy and dental implant failure rates in osteoporotic female patients.

Data: This Systematic Review is registered on PROSPERO (Registration no- CRD42025629509), following the PRISMA statement and PICOS question.

Source: An electronic literature search was carried through PubMed, Google Scholar, Scopus, Web of Science, and Cochrane Library databases from year 2008 and 2024. The focused question was: “Does bisphosphonate therapy affects dental implant failure in osteoporotic females?”

Results: In 10 studies selected for this systematic review, most studies reported high implant success rates (86%–100%) in osteoporotic females on bisphosphonates. While a few studies noted increased failure risk, particularly with longer treatment duration, the majority found no significant negative impact. Overall, bisphosphonates did not consistently affect implant outcomes.

Conclusion: The present systematic review suggests that dental implants in osteoporotic females on bisphosphonate therapy generally show high success rates. Although some studies suggest a potential increase in failure risk, especially with prolonged use, most evidence indicates that bisphosphonates do not significantly compromise implant outcomes when proper clinical protocols are followed.