Inflammatory and Metabolic Biomarkers Predicting Outcome after Ischemic Stroke.

Abstract

Ischemic stroke is one of the leading global causes of death and long-term disability. The clinical outcome of stroke differs from individual cases, thus, it is badly required for prognosis and for developing reliable biomarkers. Both inflammatory and metabolic pathways play a critical role in the pathophysiology of ischemic brain injury. The study set out to investigate the prognostic value of inflammatory and metabolic biomarkers among the outcome of ischemic stroke. Systematic review based on PRISMA for the identification of articles. An online search was made of electronic database like PubMed, Scopus, and Web of Science, Cohrane, published between 2014 and 2025. All studies examining inflammatory and metabolic biomarkers and correlation with stroke outcomes were selected for inclusion. In total, 1378 records were found and 42 studies met the inclusion criteria. the inflammatory market such as CRP, IL-6 and TNF-α is shown to be highly elevated, predictive of a poor neurological outcome and the risk of death. The metabolic biomarkers like glucose, lactate and components of lipid profiles are significantly associated with the severity of stroke and recovery. Combined biomarkers model shown better prognostic ability than just the individual biomarkers