Hybrid Gastro-Retentive Microsphere System Incorporating Ionic Casein Nanoparticles for Enhanced Memantine Hydrochloride Delivery

Abstract

The development of hybrid gastro-retentive microsphere systems incorporating ionic casein nanoparticles offers a promising approach for enhancing the controlled delivery of Memantine Hydrochloride, a widely used drug in the treatment of Alzheimer's disease. The system aims to improve the bioavailability of the drug by ensuring its prolonged retention in the stomach, allowing for sustained release and enhanced therapeutic efficacy. This study investigates the potential of these hybrid microspheres for the controlled release and absorption of Memantine, addressing the challenges associated with its poor solubility and rapid clearance from the body. The hybrid system combines gastro-retentive formulations with ionic casein nanoparticles, which provide improved drug solubility and controlled release. By utilizing a combination of floating microspheres and ionic casein nanoparticles, the study aims to enhance the bioavailability and therapeutic efficacy of Memantine Hydrochloride. This article examines the optimization of the system’s formulation, its characterization in terms of physicochemical properties, and its in-vitro release profile. The results suggest significant improvements in the drug's therapeutic profile, providing insights into new approaches to drug delivery systems for poorly soluble drugs. The findings will contribute to improving drug bioavailability in clinical applications for patients with Alzheimer's disease and related conditions.