Evaluation of Antiparkinsonian and Neuroprotective Effects of Hydroalcoholic Extract of Capparis Moonii Wight Fruits

Abstract

The main purpose of present research work is to assess the antiparkinson’s and neuroprotective action of hydroalcoholic extract of the Capparis Mooni Wight (HECM) fruits. Parkinson disease comes on second position among neurodegenerative condition and  characterised mainly by damage of dopaminergic neuron in the striatum's substantia nigra & dopamine loss (DA). Reported activity of Capparis Mooni plant is Anti-inflammatory, laxative, anti-diabetic, anthelmintic, antibacterial, astringent, digestive activity . Basic purpose of this research is to scientifically verify antiparkinson’s and neuroprotective activity of Capparis Mooni using suitable animal models. The antiparkinson’s and neuroprotective effects of Capparis Mooni fruits extract was examined using the bar catalepsy, locomotor activity, motor co-ordination, histopathological examination and oxidative parameters. Catalase and other assay were also performed for assessment of biochemical parameters. Using standard as ascorbic acid in UV visible spectrophotometer, evaluation of antioxidant activity by DPPH radical scavenging method were performed. The result of our work indicates that the hydroalcoholic extract significantly reduced haloperidol-induced catalepsy. It can be reported that because of its antioxidant activity and presence of flavonoids, alkaloids and polyphenols that may be essential for antiparkinson’s and neuroprotective effect. This finding confirms that Capparis Mooni extract has antiparkinson’s and neuroprotective activity.