Biomimetic Materials in Restorative Dentistry: Replicating the Structure and Properties of Dental Tissues.
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Abstract
Biomimetic materials are the materials formulated to emulate the structure, mechanical properties and, and functional properties of native dental tissues.(92) These materials are intended to preserve tooth structure, provide longevity, and enhance biological integration. To review the current evidence on biomimetic materials used for restorative dentistry, focusing on their ability to imitate the structure and properties of dental tissues and improve clinical outcomes. Systematic review following the PRISMA guidelines. Electronic databases including PubMed, Scopus, Web of Science, and the Cochrane Library were searched for studies published from January 2014 to December 2025, focusing on studies that evaluated biomimetic restorative materials, their mechanical properties, and clinical performance. Identified 1,354 total records; 42 studies met the inclusion criteria. Biomimetic materials, including bioactive composites, glass ionomer cements, and calcium silicate-based materials, exhibited favorable mechanical strength, adhesion, and biocompatibility. Mimicked dentin and enamel properties, promote remineralization, and improve restoration longevity. Clinical outcomes indicated reduced microleakage, enhanced marginal integrity, and improved secondary caries resistance. Biomimetic materials represent a promising direction in restorative dentistry, allowing for the replication of properties of natural dental tissues and improving long-term clinical outcomes. Their integration into clinical practice aids means of minimally invasive and biologically focused treatment strategies.