Evaluation of Serum Lipid Profile, Homocysteine and C- Reactive Protein (CRP)In Smokers and Non-Smokers

Abstract

Background: In comparison to non-smokers, cigarette smoking is regarded as a high risk factor that might result in tissue damage and complaints, including atherosclerosis, cerebral vascular disease, and cardiovascular disease. Smoking intensity and duration change the levels of triglycerides (TG), VLDL-C, LDL-C, and total cholesterol (TC) in the blood. These are elevated, lowering HDL-C levels while raising serum homocysteine and CRP levels.Aim and Objectives:The aim of the study is to investigate and compare the level of serum lipid profile, Homocysteine and CRP level, in smokers and non-smokers.Materials and Methods:The study was to examine the levels of CRP, homocysteine, and serum lipid profile in smokers and non-smokers. For this study, a total of 100 subjects were enrolled and split into two groups: Group I was the Control group (n = 50, non-smokers) and Group II was the Case group (n = 50, smokers). The study was carried out at the KarpagaVinayaga Institute of Medical Science and Research Centre, Madhuranthagam, Chengalpattu, in the departments of clinical biochemistry and general medicine.Results:According to the current study, smokers' serum total cholesterol was substantially higher (175.9 ± 51.04) than nonsmokers' (155.2 ± 39.40). While the LDL level was considerably elevated at 107.9 ± 41.44 in smokers and 91.16 ± 33.48 in nonsmokers, the VLDL level was 29.50 ± 10.14 in smokers and 19.68 ± 7.84 in nonsmokers. Smokers' serum homocysteine mean and SD were 13.87±4.29, while nonsmokers' were 11.39± 3.14. After measuring the CRP level, the mean value rose to 7.823 ± 3.36 for smokers and 5.919 ± 2.25 for nonsmokers. In comparison to the control group, all measures are statistically significant.Conclusion:In order to change the serum lipid profile and raise the levels of homocysteine and CRP, smoking intensity and duration increase.