Histopathological Correlation of Prostate Cancer with CT Scan Findings
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Abstract
Background: Prostate cancer is one of the most common malignancies in men worldwide, with early detection and accurate staging being critical for effective management and improved outcomes. This study aims to evaluate the correlation between CT scan findings and histopathological grade in patients with prostate cancer.
Methods: This cross-sectional study at the Department of Radiology and Imaging, Bangladesh Medical University, and the National Institute of Kidney Diseases and Urology, Dhaka, Bangladesh, included 100 male patients with elevated PSA or abnormal DRE who underwent CT imaging and histopathological evaluation. Tumors were classified by Gleason score, CT scans were assessed for mass, extracapsular extension, lymph node enlargement, and bone metastasis, and findings were correlated with histopathology using SPSS with p < 0.05 considered significant.
Results: Among 100 patients (mean age 66.4 ± 7.2 years, range 51–82), 20.0% had Gleason 6, 35.0% Gleason 7, 25.0% Gleason 8, and 20.0% Gleason 9–10 tumors. CT scans showed a visible prostate mass in 75.0%, extracapsular extension in 30.0%, pelvic lymph node enlargement in 25.0%, and bone metastasis in 10.0%. Mass detection increased with grade from 60.0% in Gleason 6 to 88.0% in Gleason 8 (p = 0.145), while extracapsular extension and lymph node involvement rose significantly from 0.0% in Gleason 6 to 60.0% in Gleason 9–10 (p < 0.001 for both).
Conclusion: CT scan findings correlate with histopathological grade in prostate cancer, with higher-grade tumors more likely to show extracapsular extension and lymph node involvement, supporting its role in staging and clinical management..