Evaluation of Ornidazole and Metronidazole as Adjuncts to Non-Surgical Periodontal Therapy: A Clinical Evaluation

Abstract

Introduction: Periodontal disease is agitating condition of periodontium involving both host immune system and pathogens and altering the unification of teeth supporting tissues. The removal of pathogenic flora with combination of SRP & LDD agents can be an effective approach.

Objectives: To appraise effectiveness of sub gingival application of ornidazole & metronidazole adjuvant to non-surgical periodontal therapy in managing periodontal disease.

Material & Methods: 70 patients splitted into 2 groups. Group 1 (35 subjects) were selected for subgingival placement of Ornidazole and Group 2 (35 subjects) were selected for subgingival placement of Metronidazole. Clinical parameters PI, GI, PD and CAL were assessed at baseline, one month and three months.

Results: Results showed significant betterment in clinical variables.  The clinical variables showed substantial decrease in PI, GI, PD and gain in CAL from baseline to three months of time interval group 1 as compared to group 2.

Conclusion: within the limitations and based on the clinical variables, therapy with LDD both ornidazole and metronidazole enhances the benefits in non-surgical periodontal therapy