Clinicopathological Patterns of Invasive Ductal Carcinoma in Bangladeshi Women Based on Core Biopsy Findings

Abstract

Background: Breast cancer is the most common malignancy among women worldwide and represents a growing public health challenge in low- and middle-income countries. Invasive ductal carcinoma is the predominant histological subtype and demonstrates variable clinicopathological characteristics. Tumor grading on core biopsy plays a critical role in prognostic assessment and treatment planning. This study aimed to evaluate the clinicopathological patterns of invasive ductal carcinoma in Bangladeshi women based on core biopsy findings.

Methods: This cross-sectional observational study was conducted at the Department of Surgery, Bangladesh Medical University (BMU), Dhaka, from January to December 2025. A total of 125 female patients with histopathologically confirmed invasive ductal carcinoma on core needle biopsy were included. Demographic and histopathological data were analyzed using SPSS version 25.0.

Results: The mean age was 46.8 ± 13.3 years and 58.4% of patients were below 50 years. Right breast involvement was observed in 62.4% of cases. The median largest core dimension was 1.5 cm and the median number of tumor-involved cores was 5. Grade 2 tumors predominated (71.2%), followed by Grade 1 (15.2%) and Grade 3 (13.6%). Most tumors demonstrated intermediate scores for tubule formation, pleomorphism and mitotic activity. Grade 2 tumors were consistently common across all age groups.

Conclusion: Intermediate-grade invasive ductal carcinoma predominates among Bangladeshi women diagnosed on core biopsy, with a substantial proportion presenting at a relatively younger age. Accurate histological grading remains essential for guiding management strategies.