To Investigate the Nephroprotective Activity of Plant-Derived Alkaloids Against Drug-Induced Kidney Injury

Abstract

Drug-induced kidney injury is a common side effect of many medicines such as antibiotics, painkillers, and anticancer drugs. It mainly occurs due to oxidative stress, inflammation, and damage to kidney cells, which leads to reduced kidney function.

The aim of this study is to investigate the nephroprotective activity of plant-derived alkaloids against drug-induced kidney injury. Plant alkaloids are known for their antioxidant and anti- inflammatory properties, which may help protect kidney tissues from damage.

In this study, selected plant-derived alkaloids are evaluated for their protective effects on kidney function. Their activity is assessed by measuring biochemical markers such as serum creatinine and blood urea nitrogen, along with oxidative stress parameters and histopathological changes in kidney tissue.

The findings suggest that plant-derived alkaloids may reduce oxidative stress, decrease inflammation, and protect kidney structure and function from drug-induced damage.

Thus, plant-derived alkaloids may serve as promising natural agents for preventing and managing drug-induced kidney injury.