Correlation of Lipid Sub-Fractions in Angiographically Proven Coronary Artery Disease Patients.
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Abstract
Background:- Aging is marked by a decrease in biological functions and lesser cellular resistance to stress. It is known that longevity is a characteristic that is influenced by severalgenes, among that is Apo-lipoprotein (APO) genes. An Apo protein has impact on processes relatedto cellular stress response possibly, due to connections among mitochondrial functions, endoplasmicreticulum stress and immuneresponse. This is the reason that Apo-proteins may be risk factors for development of certain diseases related to atherosclerosis, notablycoronary artery disease. Therefore, we have intended to carry out this study of correlation of Apo A1/Apo B for estimating atherogenecity in relation to its ratio with severity of coronaryartery disease.
Objective:- Study of correlation of lipid sub-fractions with severity of coronary artery disease in angiographically proven cases.
Methodology:- Prospective Observational Study, 126 Patients, conducted at MGM Medical College and Hospital, Chh. Sambhajinagar.
Results:- Lipid profile analysis revealed higher levels of total cholesterol, LDL, triglycerides,and APO Bin DVD and TVD compared to SVD, with significant differences noted.
Conclusion: Elevated levels of total cholesterol, LDL, triglycerides, APOB were significantly associated with more severe forms of CAD, highlighting these lipid sub-fractions as key markers for disease severity. The finding sunder scores the importance of managing lipid levels and comorbid conditions in CAD patients to mitigate disease progression.