Optimizing the Extractions of Gastroprotective Activity from Plant Extract

Abstract

Introduction

Traditionally, K. africana fruit has been used to treat a broad range of ailments and belongs to the Bignoniaceae family. The purpose of the study was to thoroughly evaluate the gastroprotective potential of K. africana fruit extract using the pylorus ligation method.

Objectives

This paper aims to evaluate the impact of the extraction process on the gastroprotective activity of Kigelia africana fruit extracts.

Methods

The pylorus ligation method was used to evaluate the gastroprotective activity of Soxhlet and maceration extracts.

Results

At the dose of 200 mg/kg^, the volume of acid, total acidity, ulcer index, and total protein were significantly reduced as compared to the control group; on the other hand, pH was significantly increased in both the test drug and the control group. The result of the study shows that Soxhlet and maceration extracts of K. africana showed significant (P<0.001) gastroprotective activity as compared to the control group.

Conclusion

The findings demonstrate that Soxhlet and maceration extract of Kigelia Africana showed significant gastroprotective activity as compared to the control group.