A Novel in Situ Gel an Alternative Strategy for Increased Therapeutic Efficiency.
Main Article Content
Abstract
In situ gelling drug delivery system have emerging a significant approach during the last decade are in a sol-state before injection, and they can gel in response to a number of endogenous cues, such as a rise in temperature, a shift in pH, or the presence of ions . This system is a promising new drug delivery technique that offers controlled and extended drug release due to its unique "sol-to-gel" transition property. Among the polymers used to make in situ gels is gellan gum, pectin, alginic acid, xyloglucan, chitosan. By providing extended and sustained pharmacological activity, these polymer-based formulations perform better than conventional systems. The main subjects of this review were the introduction, advantages, disadvantages, polymers used, in situ formation mechanism, techniques, and features for producing in situ gels.
Objectives: Main subjects of this review were the introduction, advantages, disadvantages, polymers used, in situ formation mechanism, techniques, and features for producing in situ gels. This system is a promising new drug delivery technique that offers controlled and extended drug release due to its unique "sol-to-gel" transition property.
Methods: In-situ gel formation triggered by various Mechanism like Temperature trigger In situ gel, pH triggered In-situ gel, and Ion triggered In-situ gel. In-Situ gel formation occurs with the help of Various methods like Solution polymerization and cold method. Among the polymers used to make in situ gels is gellan gum pectin, alginic acid, xyloglucan, chitosan.
Results: This system helpful for providing Various therapeutic and healthcare application by decreasing repeated administration, prolonging drug Release and patient therapeutic results. Resulting in highly functional but challenging dosage form.
Conclusions: By providing extended and sustained pharmacological activity, these polymer based formulations perform better therapeutic action than conventional systems.