Local Drug Delivery of Tetracycline Fiber (Periodontal AB Plus) in an Isolated Periodontal Pocket: A Case Report and Its Implications on Chemical Health Risk Reduction
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Abstract
Localized periodontal pockets harbor pathogenic microorganisms that contribute to chronic inflammation and progressive periodontal destruction. Systemic administration of antibiotics is associated with increased chemical burden, adverse reactions, and the risk of antimicrobial resistance. Local drug delivery (LDD) systems offer a targeted approach by delivering antimicrobial agents directly into periodontal pockets, thereby achieving therapeutic concentrations locally while minimizing systemic exposure.
This case report describes the clinical application of tetracycline fiber (Periodontal AB Plus) as an adjunct to scaling and root planing (SRP) in a 34-year-old male patient presenting with an isolated 5‑mm periodontal pocket in relation to tooth 36. Clinical and radiographic evaluation using orthopantomography revealed localized horizontal bone loss with no furcation involvement.
Phase I periodontal therapy was performed, followed by placement of tetracycline fiber after 21 days. At 3‑month follow‑up, a reduction in probing pocket depth from 5 mm to 3 mm and marked improvement in gingival inflammation were observed. No local or systemic adverse effects were reported. The present case highlights the role of LDD as a site‑specific, low‑risk chemical therapeutic modality that enhances periodontal healing while reducing systemic antibiotic exposure and associated health risks.