Non- Syndromic Multiple Dentigerous Cyst in Indian Population: A Systematic Review

Abstract

Introduction: Odontogenic cysts are epithelial lined pathologic cavities surrounded by fibrous connective tissue originating from the odontogenic apparatus. Dentigerous cyst is the 2^nd most common type of odontogenic cyst and can present as solitary or multiple lesions. While multiple dentigerous cysts are commonly associated with syndromic conditions such as Mucopolysaccharidosis type VI and Gardner’s syndrome, their occurrence in non-syndromic cases has also been reported, although it remains relatively underexplored in the literature.

Objectives: The objective of this systematic review is to explore the demographics, etiopathogenesis, treatment and prognosis of Non -syndromic multiple dentigerous cysts (NSMDCs).

Methods: Search strategy was implemented from the year 2004- 2025 (April) involving Indian population. Various databases were searched based upon the defined selection criteria. Risk of bias assessment was done using the JBI critical appraisal tool.

Results: The final 32 cases were selected. The observed age, gender and site predilections were consistent with those typically associated with dentigerous cyst. There was no reported recurrence for a period of upto 1 year and the prognosis of the lesion was good.

Conclusions: The cases of NSMDs have gradually increased over the period of time. However, there exists a significant knowledge gap regarding its true nature and etiopathogenesis, primarily due to the limited number of reported cases. Comprehensive case documentation, including detailed medical and family history, along with thorough clinical, radiographic, and histopathological investigations, is essential to enhance our knowledge regarding this entity.