A New Chemo-Selective Method For N-Nitrosation of Secondary Amines

Abstract

Nitrosation is an important industrial unit process that produces commercially valuable intermediates. The purpose of the N-Nitrosation reaction is to introduce one or more nitroso groups into the reacting molecules. This paper summarizes some of the most recent developments in the field of secondary amine N-nitrosation as reported in the literature. We discovered that p-toluenesulfonic acid is a low-cost, commercially available reagent that may be employed in a variety of organic syntheses and transformations.  We decided to do this study because of the utility of p-toluenesulfonic acid and the lack of studies on its use for N-nitrosation of secondary amines. As a result, we've opted to use p-toluenesulfonic acid-sodium nitrite as a new nitrosating agent for secondary amine N-nitrosation. We describe p-toulenesulfonic acid (p-TSA) as a proton source for secondary amine N-nitrosation under mild and diverse circumstances in this paper.