Long-Term Renal Outcomes in Patients with Autosomal Dominant Polycystic Kidney Disease

Abstract

Introduction: A common hereditary renal illness called autosomal dominant polycystic kidney disease (ADPKD) is characterised by the development of kidney cysts. Our study focused on the deterioration in renal function and the emergence of end-stage renal disease (ESRD) in order to examine the long-term renal outcomes in ADPKD patients. The great clinical importance of ADPKD, the genetic foundation of the disease, and the requirement to monitor disease progression over an extended period of time are the driving forces for this investigation.

Methods: Over a 10-year period, we observed 48 ADPKD patients with genetic confirmation in a cohort research. Clinical information was gathered at baseline and on a regular basis, including demographics, medical history, and laboratory values. Renal imaging was carried out to track cyst growth and renal volume, and estimated glomerular filtration rate (eGFR) was used to evaluate renal function. The annual rate of eGFR fall was the main finding, and the emergence of ESRD was the secondary finding.

Results: With a mean annual fall of 1.54 mL/min across the ten-year follow-up, the mean eGFR considerably decreased. ESRD occurred in a sizable majority of patients (70.6%). The clinical burden of ADPKD and the requirement for efficient therapeutic strategies are highlighted by these results, which are in line with earlier research.

Conclusion: The findings highlight the persistent nature of ADPKD and emphasise the therapeutic necessity of ongoing surveillance and successful therapies to slow the loss of renal function. In order to enhance patient outcomes and lessen the burden of ESRD, more research is required to evaluate these therapies and explore personalised therapy techniques for ADPKD patients.