Comparative Effect of Oral Pregabalin, Intravenous Fentanyl, And Dexmedetomidine During Abdominal Surgeries

Abstract

According to various past studies ,the most important aspect of anaesthesia for a better patient outcome is pre-OP sedation and CV stability during induction, LS, I and during the surgical process.Hence, in our study we have assessed the effects of P 150mg, IV F 2µg/kg, and IV Dexdos 0.25µg/kg during LS and ET-I in AS.Following IEC approval, 60 ASA physical status I and II patients aged 20–60 of both genders undergoing elective LS AS under GA were randomly assigned to two groups. While group B (n = 30) received oral P 150mg, IV F 2 g/kg, and IV Dexdos 0.25 g/kg as a 2-min infusion and group A (n = 30) received oral P 150mg with IV F 2 g/kg. .Before anesthesia, a comprehensive investigation was done. Before entering the OT, the patient received lactated Ringer's solution through a 20G cannula in their non-dominant hand's dorsum. Additionally, baseline parameters included HR,SBP,DBP, MABP, and SpO2 and RSS was used to assess patients' level of sedation prior to study medication administration and prior to intubation. We found that, the incidence of post-OP analgesic requirements was similar in both groups. We come to conclude that low-dose IV dexdos (0.25 μg/kg) efficiently reduced RR compared to Group A. Additionally, it improved sedation prior to I and reduced the pre-LG pressure response in LSAS. However, when compared to Group A, it did not increase intra-OP and posto-OP analgesic requirements.