Comparative Effect of Microneedling with I-Prf and Normal Saline on An Atrophic Acne Scar

Abstract

Apart from traditional methods, the utilization of injectable platelet-rich fibrin (i-PRF) for the treatment of AS is increaseing day by day. It is characterized by a high concentration of P that has efficacy of expediting tissue restoration and wound healing.Due to its properties, nowddays its acceptance is slowly increasing.Therefore, in our research endeavor, we have chosen to conduct a comparative analysis to assess the efficacy of MN with i-PRF against MN with NS for the treatment of AAS. Our study was carried out in cohort of 25 patients with thorough patient history, encompassing details such as the patient's age, SES, RA,PMH, SP, and any other past medical information, AS assessment by  Goodman and Baron for grades. Finally we placed ,i-PRF with MN on the R side of the face and NS with MN on the L side of the face. We found that one patient developed a secondary infection after 5 days of Clindamycin 1% cream for 15 days. Following that, only one patient had hyperpigmentation on both cheeks after the fourth sitting. Further, postinflammatory alterations or sun exposure may cause hyperpigmentation. With topical desonide 0.5% cream and sunscreen, healing occurs in 3 weeks. Thus, we come to the conclusion that I-PRF is a safe and effective way to treat AAS, especially box and rolling scars, with MN. Further research is necessary to enhance our comprehension of the pathophysiology of i-PRF and its impact on AAS.