Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds

Abstract

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J₁-J₅ derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J₁-J₅ derivatives. The compounds J₁-J₅ were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg ml^-1 for J₄ against the two pathogenic bacteria, while J₁, J₄, and J₁ did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4), inhibited the development of both gram-negative and positive bacteria.