Trace Element Imbalance in Patients with Combined Digestive and Renal Pathology Complicated with COVID-19

Document Type : Original Article

Authors

1 Administrative Department, Bogomolets National Medical University, Kyiv, Ukraine

2 Department of Propedeutical Internal Medicine No. 2, Bogomolets National Medical University, Kyiv, Ukraine

10.22034/jchr.2021.686477

Abstract

Diagnosis and treatment of digestive lesions remain the hold the limelight of both practitioners and scientists. Their combination worsens the prognosis in patients with chronic kidney disease in chronic glomerulonephritis, there is an imbalance of trace elements, which negatively affects the course of the disease and increases the risk of such complications. The paper aims to study the effect of Minerol on the clinical manifestations of the disease in patients with combined damage to the gastroenterological zone (chronic gastroduodenitis, peptic ulcer disease) and kidneys (chronic glomerulonephritis and pyelonephritis) according to clinical, laboratory and instrumental research methods. The diagnosis was verified by esophagogastroduodenoscopy with targeted biopsy, X-ray method, ph-metry, ultrasound; association with Helicobacter pylori – according to biopsy urease and respiratory tests, the presence of urinary syndrome − generally accepted laboratory methods, and radionuclide methods, if necessary. Patients were divided into two groups aged 18-60 years. When included in the complex treatment of gastroduodenal zone and kidney lesions, the biologically active drug Minerol contributes to a faster recovery of patients and plays an indispensable role in the prevention of complications such as uremic anaemia, cardiomyopathy, etc., providing anti-inflammatory and sanogenetic effects, can be useful in the treatment of post COVID syndrome.

Keywords


  1. Alyammahi S.K., Abdin S.M., Alhamad D.W., Altell A.T., Omar H.A., The dynamic association between COVID-19 and chronic disorders: An updated insight into prevalence, mechanisms and therapeutic modalities. Infection, Genetics and Evolution. 87, 104647.
  2. Dahiya D.S., Kichloo A., Albosta M., Pagad S., Wani F., 2020. Gastrointestinal implications in COVID-19. Journal of Investigative Medicine. 68(8), 1397-1401.
  3. Athari S.Z., Mohajeri D., Nourazar M.A., Doustar Y., 2020. Updates on coronavirus (COVID-19) and kidney. Journal of Nephropathology. 9(4), e34.
  4. Ashraf O., Young M., Malik K.J., Cheema T., 2020 Systemic complications of COVID-19. Critical Care Nursing Quarterly. 43(4), 390-399.
  5. Zaim S., Chong J.H., Sankaranarayanan V., Harky A., 2020. COVID-19 and multiorgan response. Current Problems in Cardiology. 45(8), 100618.
  6. Borisenko L.M., Batechko S.A. “Minerol” in the Program of Endoscopic Rehabilitation of the Person, Kyiv: SPD Veres O.I., 2006.
  7. Svintsitsky A.S., Gaevsky P. Internal Diseases. A Textbook Based on the Principles of Evidence-Based Medicine 2018/2019, Kyiv: Institute of Evidence-Based Medicine, 2018.
  8. Moiseyenko V.O., Yurzhenko N.M., Korniyenko A.O., Borisenko L.M., 2007. Dysmicroelementemia in patients with combined pathology of the digestive tract and kidneys. Current Issues of Nephrology. 13, 13-24.
  9. Deshmukh V., Motwani R., Kumar A., Kumari C., Raza K., 2021. Histopathological observations in COVID-19: A systematic review. Journal of Clinical Pathology. 74(2), 76-83.
  10. Al Nemer A., 2020. Histopathologic and autopsy findings in patients diagnosed with coronavirus disease 2019 (COVID-19): What we know so far based on correlation with clinical, morphologic and pathobiological aspects. Advances in Anatomic Pathology. 27(6), 363-370.
  11. Maghool F., Valiani A., Safari T., Emami M.H., Mohammadzadeh S., Gastrointestinal and renal complications in SARS-CoV-2-infected patients: Role of immune system. Scandinavian Journal of Immunology. 93(4), e12999.
  12. Gasmi A., Peana M., Pivina L., Dadar M., Bjørklund G., 2021. Interrelations between COVID-19 and other disorders. Clinical Immunology. 224, 108651.
  13. Chandrasekaran B., Ganesan T.B., 2021. Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review. Scottish Medical Journal. 66(1), 3-10.
  14. Lei H.Y., Ding Y.H., Nie K., Zhu P., Zhao M.Y., 2021. Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver. Biomedicine and Pharmacotherapy. 133, 111064.
  15. Zhong P., Xu J., Yang D., Hu X., Sun Y., 2020. COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms. Signal Transduction and Targeted Therapy. 5(1), 256.
  16. Nechiporenko A.Z., 1961. About the method of qualitative determination of form elements in urine and its significance in the diagnosis of chronic pyelonephritis. Urology. 26(4), 43-50.
  17. Zimnitsky S.S. Kidney Disease (Bright's Disease), Kazan: Kombinat izdatelstva i pechati TSSR, 1924.