Synthesis of New Glycine Cephalexin Condensed Polymer as Peptide Biopolymer for Controlled Release of Cephalexin

Authors

1 College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq

2 Department of Chemistry, College of Science, University of Misan, Maysan, Iraq

10.22034/jchr.2021.685036

Abstract

A new peptide-based polymer was synthesized via polymerization of cephalexin acid chloride with glycine acid chloride with molar ratio 1:1 in condensed polymer solution. This Glycine Cephalexin peptide biopolymer was characterized by different analyses of UV, FT-IR and 1H NMR spectroscopy. Also, physical properties of new synthesized Glycine Cephalexin peptide biopolymer were studied with measurement of its intrinsic viscosity at 30°C, swelling percentage in water and studying drug release in pH 4-10 at 37°C.

Keywords


  1. Chow D., Nunalee M.L., Lim D.W., Simnick A.J., Chilkoti A., 2008. Peptide-based biopolymers in biomedicine and biotechnology. Materials Science and Engineering: R: Reports. 62(4), 125-155.
  2. Shao Z., Vollrath F., 2002. Surprising strength of silkworm silk. Nature. 418(6899), 741-741.
  3. Jenkins C.L., Raines R.T., 2002. Insights on the conformational stability of collagen. Natural Product Reports. 19(1), 49-59.
  4. Mithieux S.M., Weiss A.S., 2005. Advances in protein chemistry. Elastin. 70, 437-461.
  5. Hoeve C., Flory P., 1974. The elastic properties of elastin. Biopolymers: Original Research on Biomolecules. 13(4), 677-686.
  6. Davidson J.M. 2021. Elastin: structure and biology, Connective Tissue Disease. CRC Press
  7. Duro-Castano A., Conejos-Sánchez I., Vicent M.J., 2014. Peptide-based polymer therapeutics. Polymers, 6(2), 515-551.
  8. Hatton F.L., 2020. Recent advances in RAFT polymerization of monomers derived from renewable resources. Polymer Chemistry. 11(2), 220-229.
  9. Namvari M., Biswas C.S., Wang Q., Liang W., Stadler F.J., 2017. Crosslinking hydroxylated reduced graphene oxide with RAFT-CTA: A nano-initiator for preparation of well-defined amino acid-based polymer nanohybrids. Journal of Colloid and Interface Science. 504, 731-740.
  10. Cui T., Yu J., Li Q., Wang C.F., Chen S., Li W., Wang G., 2020. Large‐scale fabrication of robust artificial skins from a biodegradable sealant‐loaded nanofiber scaffold to skin tissue via microfluidic blow‐spinning. Advanced Materials. 32(32), 2000982.
  11. Kirschning A., Monenschein H., Wittenberg R., 2001. Functionalized polymers—emerging versatile tools for solution‐phase chemistry and automated parallel synthesis. Angewandte Chemie International Edition. 40(4), 650-679.
  12. Miao W., Chan T.H., 2005. Ionic-liquid-supported peptide synthesis demonstrated by the synthesis of Leu5-enkephalin. The Journal of Organic Chemistry. 70(8), 3251-3255.
  13. Fuse S., Otake Y., Nakamura H., 2018. Peptide synthesis utilizing micro‐flow technology. Chemistry–An Asian Journal. 13 (24), 3818-3832.
  14. Mahindra A., Sharma K.K., Jain R., 2012. Rapid microwave-assisted solution-phase peptide synthesis. Tetrahedron Letters. 53(51), 6931-6935.
  15. Berger J., Reist M., Mayer J.M., Felt O., Gurny R., 2004. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications,. European Journal of Pharmaceutics and Biopharmaceutics. 57(1), 35-52.
  16. Rajabi M., McConnell M., Cabral J., Ali M.A., 2021. Chitosan hydrogels in 3D printing for biomedical applications. Carbohydrate Polymers. 117768.
  17. Pei M., Mao J., Xu W., Zhou Y., Xiao P., 2019. Photocrosslinkable chitosan hydrogels and their biomedical applications. Journal of Polymer Science Part A: Polymer Chemistry. 57(18), 1862-1871.