Carvacrol Attenuates Disrupted Lipid Profile Induced by Organophosphates in Male Wistar Rat: a Comparative Toxicity

Document Type : Original Article


1 Department of Physiology, Faculty of Sciences, Qom Branch, Islamic Azad University, Qom, Iran

2 Department of Biology, Faculty of Sciences, Qom Branch, Islamic Azad University, Qom, Iran

3 Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

4 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

5 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


Many people in agricultural industry are nowadays struggling with protecting their products utilizing pesticides. Pesticides, such as organophosphate (OPE) insecticides, may remain on agricultural products as pesticide residues. Malathion (MTN) is an OPE widely used around the world. Some OPEs, such as parathion (PTN), are more toxic pesticides and have been restricted. Carvacrol (CRL) is a major component of Satureja khuzestanica essential oil, whichexerted protective effects against toxicity of chemicals. OPEs can alter lipid profile. In addition, lipid profile may alter due to certain disorders, such as nephrotic syndrome. The present study aimed to investigate the effects of coadministration of CRL and the effect of these two pesticides on serum acetylcholinesterase (AchE) activity and lipid profile in male wistar rat. Coadministration of CRL and PTN, but not MTN, significantly decreased serum AchE activity in comparison with the group receiving OPE. Serum levels of cholesterol and triglyceride were analyzed after 10 days of administration of the chemicals. Malathion and PTN significantly increased cholesterol and triglyceride. However, administration of CRL modified lipid profile (P < 0.05). It was concluded that CRL could be considered as a drug to treat lipid profile alteration and owing to the beneficial effects as well as inhibition of acetylcholine, it could be considered as a component of OPE pesticide.


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