Assessment of Biomarkers of Oxidative Stress among Patients with Lymphoma

Document Type : Original Article

Authors

1 Department of Biology, Science and Research Branch,Islamic Azad University,Tehran,Iran

2 Department of Biology,Science and Research Branch,Islamic Azad University,Tehran,Iran

3 Department of Clinical Biochemistry,School of Medicin,Zahedan University of Medical Sciences,Zahedan,Iran

4 Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran

5 Bioprocess Engineering Group,National Institute for Genetic Engineering and Biotechnology,Tehran, Iran

10.22034/jchr.2021.1916955.1228

Abstract

The role of oxidative stress is one of the most important factors in the development of cancer. In this study, the catalase activity and total antioxidant capacity in NHL patients were measures and compared with those in healthy subjects. The population of this study consisted of 25 patients with non-Hodgkin's lymphoma, diagnosed based on pathological findings. Total antioxidant capacity (TAC) and catalase catalytic activity (CAT) were determined by spectrophotometry.  Based on the results, the CAT activity  was significantly lower and TAC was lower (0.29±0.04 vs. 2.69±0.15; P-value=0.01) in NHL patients than in healthy subjects. The findings showed that these markers could be used as a prognosis in non-Hodgkin's lymphoma that oxidative stress may also be related to the NHL or increase the risk of disease.

Keywords


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