Prevalence of Medicinal Herbs Use during Pregnancy in the World: A Systematic Review and Meta-Analysis

Document Type : Original Article

Authors

1 Assistant Professor, Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Assistant Professor, Department of Reproductive Health, Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract

The use of herbs during pregnancy is on the rise today, but some of these plants can not only cause side effects in the mother and fetus but also have drug interactions. This systematic survey and meta-analysis reading were administered to define the outbreak of herbs used by women during pregnancy. The present work was performed using the meta-analysis method from March 2000 to February 2019. The search process was carried out in Iranian databases such as SID, Regional Information Center for Science and Technology (RICST), Mag-Iran, IranDoc, Barakat Knowledge Network System, Iranian National Library and international databases such as PubMed / Medline, Cochrane Library, Scopus, Science Direct, Web of Sciences, Embase, EBSCO, and Google Scholar. keywords including medicinal herbs, Medicinal plant, Plant, Extract, Women, and pregnancy. The heterogeneity of investigations was scrutinized using the I2 index. Analysis was carried out using Comprehensive Meta-Analysis software. A total of 73 articles were contained in the meta-analysis process. Based on the results, the general outbreak of medicinal herbs use during pregnancy was 32.4% (95% CI: 28.2%-36.8%). The results of meta-regression showed that increasing in sample size leads to decreased overall prevalence of herbal medicine consumption during pregnancy and increasing in the year of research leads to increased overall prevalence of herbal drug use during pregnancy, which both were statistically significant (P <0.05).The prevalence of medicinal herbs consumption during pregnancy is relatively high.

Keywords


1. John L.J., Shantakumari N., 2015. Herbal medicines use during pregnancy: a review from the Middle East. Oman Med  J. 30(4), 229-36.
2. Dugoua J.J., 2010. Herbal medicines and pregnancy. J Popul Ther Clin Pharmacol .17(3), e370-e378.
3. Crum C.P., Nucci M.R., Granter S.R., Howitt B.E., Parast M.M., Boyd T., Peters W., 2017. Diagnostic Gynecologic and Obstetric Pathology E-Book: Elsevier Health Sciences. 77-83.
4. Orief Y.I., Farghaly N.F., Ibrahim M.I., 2014. Use of herbal medicines among pregnant women attending family health centers in Alexandria. Middle East Fertil Soc J. 19(1),42-50.
5. Dabirifard M., Maghsoudi Z., Dabirifard S., Salmani N., 2017. Frequency, causes and how to use medicinal herbs during pregnancy. Iran J Obstet. 20(4),66-75.
6. Hosseini S.H., Rajabzadeh R., Nosrati H., Naseri F., Toroski M., Mohaddes Hakkak H., Ayati M.H., 2017. Prevalence of Medicinal Herbs Consumption in Pregnant Women Referring to Bojnurd Health Care Centers. Iran J Obstet. 20(9),33-40.
7. Sereshti M., Azari P., Rafieian-Kopaei M., Kheiri S., 2006. Use of herbal medicines by pregnant women in Shahr-e-Kord. J Reprod Infertil.7(2), 125-131.
8. Abdollahi F., Khani S., Charati J.Y., 2018. Prevalence and Related Factors to Herbal Medic.ines Use among Pregnant Females. Jundishapur J Nat Pharm Prod.13(3), 1–8.
9. Mekuria A.B., Erku D.A., Gebresillassie B.M., Birru E.M., Tizazu B., Ahmedin A., 2017. Prevalence and associated factors of herbal medicine use among pregnant women on antenatal care follow-up at University of Gondar referral and teaching hospital, Ethiopia: a cross-sectional study. BMC Complem Altern M.17(1),86-103.
10. James P.,Taidy-Leigh L., Bah A.J., Kanu J.S., Kangbai J.B., Sevalie S., 2018. Prevalence and correlates of herbal medicine use among women seeking care for infertility in Freetown, Sierra Leone. Evid Based Complement Alternat Med.2018, 1–11.
11. Frawley., Adams J., Sibbritt D., Steel A., Broom A., Gallois C., 2013. Prevalence and determinants of complementary and alternative medicine use during pregnancy: results from a nationally representative sample of Australian pregnant women. Aust N Z J Obstet Gynaecol. 53(4),347-52.
12. Laelago T., Yohannes T., Lemango F., 2016. Prevalence of herbal medicine use and associated factors among pregnant women attending antenatal care at public health facilities in Hossana Town, Southern Ethiopia: acility based cross sectional study. Arch Public Health.74(1),7-25.
13. Duru C.B., Uwakwe K.A., Chinomnso N.C., Mbachi I.I., Diwe K.C., Agunwa C.C., Anthony C.I., Irene A.M., 2016. Socio-demographic determinants of herbal medicine use in pregnancy among Nigerian women attending clinics in a tertiary Hospital in Imo State, south-east, Nigeria. Am J Med Stud.4(1),1-10.
14. Ahmed M., Hwang J.H., Hasan M.A., Han D., 2018. Herbal medicine use by pregnant women in Bangladesh: a cross-sectional study. BMC Complem Altern M.18 (1),229-333.
15. Volqvartz T., Vestergaard A.L., Aagaard S.K., Andreasen M.F., Lesnikova I., Uldbjerg N.,  Larsen A.,  Bor P., 2019. Use of alternative medicine, ginger and licorice among Danish pregnant women–a prospective cohort study. BMC Complem Altern M.19(1),5-7.
16. Al Essa M., Alissa A., Alanizi A., Bustami R., Almogbel F., Alzuwayed O.,  Abo Moti M.,  Alsadoun N., Alshammari W., Albekairy A.,  Al Harbi S., Alhokail M.,  Gramish J.,  2019. Pregnant women’s use and attitude toward herbal, vitamin, and mineral supplements in an academic tertiary care center, Riyadh, Saudi Arabia. Saudi pharm j.27(1),138-44.
17. James P.B., Bah A.J., Tommy M.S., Wardle J., Steel A., 2018. Herbal medicines use during pregnancy in Sierra Leone: An exploratory cross-sectional study. Women Birth.31(5),e302-e9.
18. Kıssal A., Güner Ü.Ç., Ertürk D.B., 2017. Use of herbal product among pregnant women in Turkey. Complement Ther Med.30,54-60.
19. Frawley J., Adams J., Steel A., Broom A., Gallois C., Sibbritt D., 2015. Women's use and self-prescription of herbal medicine during pregnancy: an examination of 1,835 pregnant women. Women's Health Issues.25(4),396-402.
20. Joseph B., Ezie I., Aya B., Dapar M., 2017. Self-medication among pregnant women attending antenatal clinics in Jos North, Nigeria. Int J Trop Dis Health.21(1),1-7.
21. Chukwurah J.N., Idowu E., Adeneye A.K., Aina O.O., Agomo P.U., Otubanjo A.O., 2016. Knowledge, attitude and practice on malaria prevention and sulfadoxine-pyrimethamine utilisation among pregnant women in Badagry, Lagos State, Nigeria. MWJ.7(3),1-6.
22. Adusi-Poku Y., Vanotoo L., Detoh E., Oduro J., Nsiah R., Natogmah A., 2015. Type of herbal medicines utilized by pregnant women attending ante-natal clinic in Offinso north district: Are orthodox prescribers aware? Ghana Medical J.49(4),227-32.
23. Alaku I., Ha A.K., 2015. Epidemiology of Malaria Parasites Infection among Pregnant Women in Some Part of Nasarawa State, Nigeria. Epidemiology.5(2),30-3.
24. Bello U.L., Isah J., 2015.Use of herbal medicines and aphrodisiac substances among women in Kano state, Nigeria. IOSR J Nursing Health Sci.4(3),41-50.
25. Nergard C.S., Ho T.P., Diallo D., Ballo N., Paulsen B.S., Nordeng H., 2015. Attitudes and use of medicinal plants during pregnancy among women at health care centers in three regions of Mali, West-Africa. J Ethnobiol Ethnomedicine. 11(1), 73-83.
26. Aboyeji A.P., Ijaiya M.A., Fawole A.A., Adesina K.T., Ologe M.O., Adewara A.A., Olarinoye A.O., 2014. Pharmacological exposure of pregnant mothers in Ilorin, Nigeria. Trop J Obstet Gynaecol .31(1),17-22.
27. Emmanuel A., Achema G., Afoi B.B., Maroof R., 2014. Self Medicaltion Practice Among Pregnant Women Attending Antenatal Clinic in Selected Hospitals In Jos, Nigeria. Inter J  Nurs  Health Sci. 1(6), 55-59.
28. Omole-Ohonsi A., Aiyedun T., 2013.Use of hernal medicines in pregnancy in Aminu Kano teaching Hospital-Myth or reality. Trop J Obstet Gynaecol.30(1),80-88.
29. Olowokere A., Olajide O., 2013. Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria. Clin Nurs Stud.1(4),9-22.
30. Abasiubong F., Bassey E.A., Udobang J.A., Akinbami O.S., Udoh S.B., Idung A.U., 2012. Self-Medication: potential risks and hazards among pregnant women in Uyo, Nigeria.Pan Afr. med.13(1), 15‑19.
31. Oladeinde B.H., Omoregie R., Odia I., Oladeinde O.B., 2012. Prevalence of malaria and anemia among pregnant women attending a traditional birth home in Benin City, Nigeria. Oman med j.27(3),232–236.
32. Bello F.A., Morhason-Bello I.O., Olayemi O., Adekunle A.O., 2011. Patterns and predictors of self-medication amongst antenatal clients in Ibadan, Nigeria.Niger J Med.52(3),153-7.
33. Malan D.F., Neuba D.F., 2011.Traditional practices and medicinal plants use during pregnancy by Anyi-Ndenye women (Eastern Côte d'Ivoire). Afr J Reprod Health.15(1),85-93.
34. Tongo O.O., Orimadegun A.E., Akinyinka O.O., 2011. Utilisation of malaria preventive measures during pregnancy and birth outcomes in Ibadan, Nigeria. BMC Pregnancy Childbirth .11(1), 60-67.
35. Yusuff K.B., Omarusehe L.D., 2011. Determinants of self medication practices among pregnant women in Ibadan, Nigeria. Int J Clin Pharm.33(5),868-75.
36. Tamuno I., Omole-Ohonsi A., Fadare J., 2011. Use of herbal medicine among pregnant women attending a tertiary hospital in Northern Nigeria. Internet J Gynecol Obstet.15(2), 3-6.
37. Fakeye T.O., Adisa R., Musa I.E., 2009. Attitude and use of herbal medicines among pregnant women in Nigeria. BMC Complem Altern M.9(1),53 - 60.
38. Sam-Wobo S., Akinboroye T., Anosike J., Adewale B., 2008. Knowledge and practices on malaria treatment measures among pregnant women in Aveokuta, Nigeria. Tanzan J Health Res.10 (4)226-31.
39. Addo V., 2007. Herbal medicines: socio-demographic characteristics and pattern of use by patients in a tertiary obstetrics and gynaecology unit. J Sci Tech (Ghana).27(3),149-55.
40. Gharoro E., Igbafe A., 2000. Pattern of drug use amongst antenatal patients in Benin City, Nigeria. Med Sci Monit.6(1),84-7.
41. Nyeko R., Tumwesigye N.M., Halage A.A., 2016. Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda. BMC Pregnancy Childbirth.16(296),1-12.
42. Abeje G., Admasie C., Wasie B., 2015. Factors associated with self medication practice among pregnant mothers attending antenatal care at governmental health centers in Bahir Dar city administration, Northwest Ethiopia, a cross sectional study. Pan Afr med j. 20, 1–9..
43. Bayisa B., Tatiparthi R., Mulisa E., 2014. Use of herbal medicine among pregnant women on antenatal care at Nekemte Hospital, Western Ethiopia. Jundishapur j nat pharma prod.9(4), e17368-e17368.
44. Gebremedhin G.L., Gomathi P., 2014. Assessment of drug use and effect in pregnant women attending antenatal care in hospitals of Mekelle, Tigray, Ethiopia. J Drug Deliv Ther. 4(6),75-82.
45. Mothupi M.C., 2014. Use of herbal medicine during pregnancy among women with access to public healthcare in Nairobi, Kenya: a cross-sectional survey. BMC Complem Altern M. 14(432), 1–8.
46. Rasch V., Sørensen P.H., Wang A.R., Tibazarwa F., Jäger A.K., 2014. Unsafe abortion in rural Tanzania–the use of traditional medicine from a patient and a provider perspective. BMC pregnancy  childbirth.14(1),355-419.
47. Kaingu C.K., Oduma J.A., Kanui T.I., 2011. Practices of traditional birth attendants in Machakos District, Kenya. J ethnopharmacol.137(1),495-502.
48. Kebede B., Gedif T., Getachew A., 2009. Assessment of drug use among pregnant women in Addis Ababa, Ethiopia.Pharmacoepidemiol Drug Saf.18(6),462-8.
49. Kamatenesi-Mugisha M., Oryem-Origa H., 2007. Medicinal plants used to induce labour during childbirth in western Uganda. J Ethnopharmacol.109(1),1-9.
50. Chatanga P., Maibvise C., Mugomeri E., Seliane K., 2015. Identifying promoters and reasons for medicinal herb usage during pregnancy in Maseru, Lesotho. Afr J Nurs Midwifery .17(1),4-16.
51. Hanafy S., Sallam S., Kharboush I., Wahdan I., 2016. Drug utilization pattern during pregnancy in Alexandria, Egypt. Eur J Pharm Med Res.3(2),19-29.
52. Mbarambara P.M., Songa P.B., Wansubi L.M., Mututa P.M., Minga B.B., Bisangamo C.K., 2016. Self-medication practice among pregnant women attending antenatal care at health centers in Bukavu, Eastern DR Congo. Inter J Innovation Applied Studies.16(1),38–45.
53. Tang L., Lee A.H., Binns C.W., Van Hui Y., 2016.Yau K.K., Consumption of Chinese herbal medicines during pregnancy and postpartum: A prospective cohort study in China. Midwifery.34,205-10.
54. Kennedy D., Lupattelli A., Koren G., Nordeng H., 2016. Safety classification of herbal medicines used in pregnancy in a multinational study. BMC Complem Altern M.16(1),102-110.
55. Jaradat N., Adawi D., 2013.Use of herbal medicines during pregnancy in a group of Palestinian women. J Ethnopharmacol.150(1),79-84.
56. Kim Sooi L., Lean Keng S., 2013. Herbal medicines: Malaysian women’s knowledge and practice. Evid Based Complementary Altern Med. 2013(2), 1-10.
57. Bishop J.L., Northstone K., Green J., Thompson E.A., 2011. The use of complementary and alternative medicine in pregnancy: data from the Avon Longitudinal Study of Parents andChildren (ALSPAC).Complement Ther Med. 19(6),303-10.
58. Nordeng H., Bayne K., Havnen G.C., Paulsen B.S., 2011. Use of herbal drugs during pregnancy among 600 Norwegian women in relation to concurrent use of conventional drugs and pregnancy outcome. Complement Ther Clin Pract. 17(3),147-51.
59. Al-Riyami I.M., Al-Busaidy I.Q., Al-Zakwani I.S., 2011. Medication use during pregnancy in Omani women. Int J Clin Pharm. 33(4),634-41.
60. Tabatabaee M., 2011. Use of herbal medicine among pregnant women referring to Valiasr Hospital in Kazeroon, Fars, South of Iran. J Med Plant Res. 1(37),96-108.
61. Cuzzolin L., Francini‐Pesenti F., Verlato G., Joppi M., Baldelli P., Benoni G., 2010. Use of herbal productsamong 392 Italian pregnant women: focus on pregnancy outcome.  Pharmacoepidemiol Drug Saf. 19(11),1151-8.
62. Lapi F., Vannacci A., Moschini M., Cipollini F., Morsuillo M., Gallo E.,  Banchelli G.,  Cecchi E.,  Di Pirro M.,  Giovannini M.G.,  Cariglia M.T.,  Gori L.,  Firenzuoli F.,  Mugelli A., 2010. Use, attitudes and knowledge of complementary and alternative drugs (CADs) among pregnant women: a preliminary survey in Tuscany.Evid Based Complementary Altern Med.7(4),477-86.
63. Nordeng H., Havnen G.C,. 2004. Use of herbal drugs in pregnancy: a survey among 400 Norwegian women.Pharmacoepidemiol Drug Saf. 13(6),371-80.
64. Bercaw J., Maheshwari B., Sangi‐Haghpeykar H., 2010. The use during pregnancy of prescription, over‐the‐counter, and alternative medications among Hispanic women. Birth.37(3),211-8.
65. Broussard C.S., Louik C., Honein M.A., Mitchell A.A., 2010. Study NBDP. Herbal use before and during pregnancy. Am J Obstet Gynecol.202(5),443. e1-. e6.
66. Zhu X., Qi X., Hao J., Huang Z., Zhang Z., Xing X., 2010. Pattern of drug use during the first trimester among Chinese women: data from a population-based cohort study.Eur J Clin Pharmacol.66(5),511-8.
67. Holst L., Wright D., Haavik S., Nordeng H., 2009. The use and the user of herbal remedies during pregnancy. J Altern Complement Med .15(7),787-92.
68. Chuang C.H., Chang P.J., Hsieh W.S., Tsai Y.J., Lin S.J., Chen P.C., 2009. Chinese herbal medicine use in Taiwan during pregnancy and the postpartum period: a population-based cohort study. Int J Nurs. 46(6),787-95.
69. Yeh H.Y., Chen Y.C., Chen F.P., Chou L.F., Chen T.J., Hwang S.J., 2009. Use of traditional Chinese medicine among pregnant women in Taiwan. Int  J Gynecol Obstet.107(2),147-50.
70. Chuang C.H., Hsieh W.S., GuoY.L., Tsai Y.J., Chang P.J., Lin S.J.,  Chen P.C., 2007. Chinese herbal medicines used in pregnancy: a population‐based survey in Taiwan. Pharmacoepidemiol Drug Saf.16(4),464-8.
71. Forster D.A., Denning A., Wills G., Bolger M., McCarthy E., 2006. Herbal medicine use during pregnancy in a group of Australian women.BMC Pregnancy Childbirth.6(1), 10-21.
72. Nordeng H., Havnen G.C., 2005. Impact of socio-demographic factors, knowledge and attitude on the use of herbal drugs in pregnancy. Acta Obstet Gynecol Scand. 84(1),26-33.
73. Tsui B., Dennehy C.E., Tsourounis C., 2001. A survey of dietary supplement use during pregnancy at an academic medical center. Am J Obstet Gynecol.185(2),433-7.
74. Sattari M., Dilmaghanizadeh M., Hamishehkar H., Mashayekhi S.O., 2012.Self-reported use and attitudes regarding herbal medicine safety during pregnancy in Iran. Jundishapur J nat pharma prod.7(2), 45–49.
75. Sawalha A.F., 2007. Consumption of prescription and non-prescription medications by pregnant women: a cross sectional study in Palestine. IUG J  Natural Studies.15(2) ,41-57.
76. Hashim M., Johina A., Deyaa K., Fareed M., Mohamed H., Faten A., 2005. Knowledge attitude and practice of complementary and alternative medicine (CAM) among pregnant women: a preliminary survey in Qatar. Middle East J Fam Med. 7(10),6-14.
77. Khadivzadeh T., Ghabel M., 2012. Complementary and alternative medicine use in pregnancy in Mashhad, Iran, 2007-8.Iran J Nurs Midwifery res. 17(4),263-9.
78. Adawi D.H., 2012. Prevalence and Predictors of Herb Use during Pregnancy (A study at Rafidia Governmental Hospital/Palestine).p.5-7. Available at http://scholar .najah .edu/sites/default/files/all-thesis/deema_adawi.pdf. Accessed February 3, 2018.
79. Ahmed S.M., Nordeng H., Sundby J., Aragaw Y.A., de Boer H.J., 2018. The use of medicinal plants by pregnant women in Africa: A systematic review. J Ethnopharmacol.224,297-313.
80. Louik C., Gardiner P., Kelley K., Mitchell A.A., 2010. Use of herbal treatments in pregnancy. Am J of obstet gynecol.202(5),439. e1-e10.
81. Holst L., Nordeng H., Haavik S., 2008. Use of herbal drugs during early pregnancy in relation to maternal characteristics and pregnancy outcome. pharmacoepidemiology and drug safety.17(2),151-9.
82. Hall H.G., Griffiths D.L., McKenna LG., 2011. The use of complementary and alternative medicine by pregnant women: a literature review. Midwifery.27(6),817-24.
 
Volume 12, Issue 2
May 2022
Pages 183-196
  • Receive Date: 06 January 2020
  • Revise Date: 19 May 2020
  • Accept Date: 18 October 2020
  • First Publish Date: 02 November 2020