Brief Discussion on Mercury Poisoning, Its Sources and Remedies to Cure It

Document Type : Original Article

Author

PhD Scholar, Institute of chemical sciences, Bahaudin Zakaraya University, Multan, Pakistan

Abstract

The review briefly focuses the wide usage of sources of mercury, despite its hazardous effects. This study is aimed at the search for alternate sources of the mercury, in order to minimize its poisoning effects. This review elaborates the precautionary measures which may be adopted to reduce mercury poisoning. Due to its multifunctional properties in different fields of life, mercury has actually proved a necessary poison up till now. Previously mercury toxicity in human life was considered minimal because of ignorance about the hazards created by even very low amounts of mercury exposures to human body. Mercury poisoning can cause serious chronic and neurological disorders in humans if they are exposed to it for longer times. Fetal autism disorders areone of the critical aspects caused by mercury exposures of pregnant women. After Minamata mercury poisoning influences, there is a strict need to use alternative materials of mercury in order to reduce mercury poisoning. Methods to reduce mercury poisoning include the use of alternative materials like polymer resins rather than mercury.Case study of this review briefly discusses the mercury sources, mercury hazards and precautionary measures of mercury poisoning, related to present age. Concluding remarks elaborate that mercury poisoning can be reduced if some precautions are adopted.

Keywords

References

1. Eyeson J., House I., Yang Y.H., Warnakulasuriya K., 2010. Relationship between mercury levels in blood and urine and complaints of chronic mercury toxicity from amalgam restorations.Brit Dent Jour.208,162-3.
2. Homme K.G., Kern, J.K., Haley B.E., Geier, D.A., King, P.G., Sykes, L.K., 2014. New science challenges old notion that mercury dental amalgam is safe.Biometals.27, 19-24.
3. Palkovicova L., Ursinyova, Masanova M.V., Yu Z., Hertz-Picciotto I.,2008. Mercury in the Environment: Pattern and Process.JourExpoSciEnvironEpidem.18,326-31.
4. Soussa E.Y., Maria O.M., 2013. Evaluation of oral tissue response and blood levels of mercury released from dental amalgam in rats.Arch Oral Biol.58,981-8.
5. Mortazavi S.M., MotamedifarG M., Shokrpour N., 2013. Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation.Dose Response.12,233-45.
6.Hong Y.S., Kim Y.M., Lee K.E., 2012. Methylmercury exposure and health effects. Journal of Preventive Medicine and Public Health = YebangUihakhoe Chi. 45(6), 353–63. 
7.Mortazavi S.M., Taeb S., Dehghan N., 2013.Iranian Journal of Public.42, 428-35.
8. Mortazavi S.M., Rouintan M.S., Taeb S., Dehghan N., Sadeghi A., 2012.Human short-term exposure to electromagnetic fields emitted by mobile phones decreases computer-assisted visual reaction time.Acta Neurol Belg.112,171-5.
9. Mortazavi S., Mosleh-Shirazi Tavassoli M.A., Taheri M., Mehdizadeh Namazi A.S.,2012.Increased Radioresistance to Lethal Doses of Gamma Rays in Mice and Rats after Exposure to Microwave Radiation Emitted by a GSM Mobile Phone Simulator.Dose Response.11,281-92.
10. Mortazavi S., Mosleh-Shirazi M., Tavassoli A., Taheri M., Bagheri Z., Ghalandari R., 2011. A comparative study on the increased radioresistance to lethal doses of gamma rays after exposure to microwave radiation and oral intake of flaxseed oilIranian. Journal of Radiation Research.9, 9-14.
11. Mortavazi S., Habib A., Ganj-Karami A., 2009.Alterations in TSH and Thyroid Hormones following Mobile Phone Use.Oman Med Jour.24, 274-8.
12. Mortazavi S.M., Daiee E., Yazdi A., Khiabani Kavousi K., Vazirinejad A.R., 2008. Mercury release from dental amalgam restorations after magnetic resonance imaging and following mobile phone use.Pak Jour Bio Sci.11,1142-6.
13. Mortazav S.M., Ahmadi J., Shariati M., 2007. Prevalence of subjective poor health symptoms associated with exposure to electromagnetic fields among university students. Bioelectromagnetics. 28, 326-30. 
14. Bernardo M., Martin M.D., Lerouz B.G., 2007. Survival and reasons for failure of amalgam versus composite posterior restorations placed in a randomized clinical trial. The Jour of the Amer Dent Assoc. 138, 775–783. 
15. Fuks A.B., 2002.The use of amalgam in pediatric dentistry. Jour Pedia Dent. 24, 448–455.
 16.  Guzzi G., Grandi M., Cattaneo C., 2006. Dental amalgam and mercury levels in autopsy tissues: Food for thought. American Journal of Forensic Medicine and Pathology. 27, 42–45.
17.  Murad  M., 2009. No available evidence to assess the effectiveness of bonded amalgams. Evidence Based Dentistry. 10, 106-119.
18. Chandrasekhar V., 2018. Incremental techniques in direct composite restoration. Journal of Conservative Dentistry. 13, 23–27. 
19. Jansson T., 2001. Amino acid transporters in the human placenta.Pediatric Research. 49, 141–147.
20. Avagliano L., GaròC., Marconi A.M., 2012. Placental Amino Acids Transport in Intrauterine Growth Restriction. Jour Preg. 1-6.
21. Mortazavi Gh., Haghani M., Rastegarian N., Zarei S., 2016. Increased Release of Mercury from Dental Amalgam Fillings due to Maternal Exposure to Electromagnetic Fields as a Possible Mechanism for the High Rates of Autism in the Offspring & 58; Introducing a Hypothesis J. Mortazavi. Journal of Biomedical Physics & Engineering. 6, 41–46. 
22. Boylan H.M., Cain R.D., Kingston H.M., 2013. A New Method to Assess Mercury Emissions:  A Study of Three Coal-Fired Electric-Generating Power Station Configurations. Journal of the Air and Waste Management Association. 53, 1318–1325.
23. Zeitz P., Orr M.F., Kaye W.E., 2002. Public health consequences of mercury spills: Hazardous Substances Emergency Events Surveillance system, 1993-1998.Environmental Health Perspectives. 110, 129–132,
24. Burger J., Jeitner C., Gochfeld M., 2011. Locational Differences in Mercury and Selenium Levels in 19 Species of Saltwater Fish from New Jersey. Journal of Toxicology and Environmental Health. 74, 863–874.
25.Maqbool  F., 2014. Exposure to Mercury from Dental Amalgams: A Threat to Society. Archives of industrial hygiene and Toxicology. 65, 339-340
26. Bjorkman L., Lundekvam B.F., Lægreid T., 2007. Mercury in Human Brain, Blood, Muscle and Toenails in Relation to Exposure: An Autopsy Study. Environmental Health. 6,30-45.
27. Mutter J., Curth A., Naumann, J., Deth R., Walach H., 2010. Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism. Journal of Alzheimer’s Disease. 2, 357–374.
28. Crespo-Lopez M.E., Macedo G.L., Pereira S.I.D., 2009. Mercury and human genotoxicity: critical considerations and possible molecular mechanisms.Pharmacol Res. 60, 212–220.
29. Aschner M., Onishchenko N., Ceccatelli S., 2010. Toxicology of Alkylmercury Compounds. Metal Ions in Life Sciences. 7, 403–423.
30. Mortazavi G., Mortazavi S.M.J., Increased mercury release from dental amalgam restorations after exposure to electromagnetic fields as a potential hazard for hypersensitive people and pregnant women. Reviews on Environmental Health. 30, 40-64.  
31. Neghab M., Choobineh A., Hassan Zadeh J., Ghaderi E., 2011. Symptoms of Intoxication in Dentists Associated with Exposure to Low Levels of Mercury. Industrial Health. 49, 249-54.
32. Joshi A., Douglass C.W., Kim H.D., Joshipura K.J., Park M.C., Rimm E.B., Carino M.J., Garcia R.I., Morris J.S., Willett W.C., 2003. The relationship between amalgam restorations and mercury levels in male dentists and nondental health professionals. J Public Health Dent. 63, 52-60.
33. Karahalil B., Rahravi  H., Ertas N.,2005. Examination of urinary mercury levels in dentists in Turkey. Human Exposure Toxicology. 24, 383-8.
34. Sletvold H., Svendsen  K., Aas O., Syverson T., Hilt B., 2012. Cognitive‐emotional sensitization and somatic health complaints. Scandian Journal of  Psychology. 53,136-43.
35. Ritchie K.A., Gilmour W.H., Macdonald E.B., Burke F.J.T., 2002. Dynamics of Mercury Pollution on Regional and Global Scales.Occupational Environment Medicine. 59, 287-93.
36. Natasha N., 2017. A Review of Mercury Exposure and Health of Dental Personnel. Saf Health Work. 8, 1–10.
37. Aydin N., KaraoglanogluS.,Yigit A., Keles S.M., Kirpinar I., 2003. Seven N., Dental amalgam and human health. International Dental Journal. 53,  85-91.
38. Bose-O'Reilly S., McCarty K.M., Steckling N., Lettmeier  B., 2010. Mercury exposure and children's health, Current Problems in Pediatric and Adolescent Health Care. 40(8), 186-215
39. Levy M., 1995. Dental Amalgam: toxicological evaluation and health risk assessment. J Can Dent Assoc. 61, 667–8.
40. Goldman L.R., Shannon M.W., 2001. Technical report: mercury in the environment: implications for pediatricians. Pediatrics. 108 (1), 197–205. 
41.  Mercury danger in dolphin meat. 2009. Archived 2012-06-30 at Archive.today.
42. "Archived copy". Archived from the original on 2015-04-08. Retrieved 2015-04-08.
43.  Pacyna E.G., Pacyna J.M., Steenhuisen F., Wilson S., 2006. Global anthropogenic mercury emission inventory for 2000. Atmos Environ. 40(22), 4048–63. Bibcode:2006AtmEn.40.4048P. doi:10.1016/j.atmosenv.2006.03.041.
44.  How mercury poisons gold miners and enters the food chain Archived 2013-09-23 at the Wayback Machine, BBC News
45. United States Environmental Protection Agency1997. Mercury Study Report to Congress (PDF). 4. Washington, D.C.: United States Environmental Protection Agency. Archived (PDF) from the original on 2011-02-03.
46. Lynch E., Braithwaite R., 2005. A review of the clinical and toxicological aspects of 'traditional' (herbal) medicines adulterated with heavy metals. Expert Opinion on Drug Safety. 4(4), 769 – 78. doi: 10. 1517/14740338. 4 .4. 769. PMID 16011453.
47. Doja A., Roberts W., 2006. Immunizations and autism: a review of the literature. Can J Neurol Sci. 33(4), 341–6. doi:10.1017/s031716710000528x. PMID 17168158.
48.  Thompson W.W., Price C., Goodson B., 2007. Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years. N Engl J Med. 357 (13), 1281–92. doi:10.1056/NEJMoa071434. PMID 17898097. Archived from the original on 2010-07-22.
49. The Karen Wetterhahn story Archived 2012-04-17 at WebCite – University of Bristol web page documenting her death, retrieved December 9, 2006.
50. OSHA update following Karen Wetterhahn's death Archived 2015-07-11 at the Wayback Machine.
51. Clifton JC 2nd2007. Mercury exposure and public health. Pediatr Clin North Am. 54 (2), 237–69, viii. doi:10.1016/j.pcl.2007.02.005. PMID 17448359.
52. Jeffrey S., Paul A., 2009. "Vaccines and Autism: A Tale of Shifting Hypotheses". Clinical Infectious Diseases. 48(4), 456 – 461.  doi: 10.1086/ 596476.  PMC  2908388.  PMID 19128068. Archived from the original on 2013 – 10 - 31.
53. Mahaffey K.R., 2001. Exposure to Mercury in the Americas. Dynamics of Mercury Pollution on Regional and Global Scales. doi:10.1007/0-387-24494-8_15. ISBN 978-0-387-24493-8.pp. 345–384. 
54. Mozaffarian D., Rimm E.B., 2006. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 296(15), 1885–99. doi: 10. 1001/jama. 296.15. 1885. PMID 17047219. Archived from the original on 2010-12-02.
55.  Rice D.C., Barone S., 2000. Critical periods of vulnerability for the developing nervous system: evidence from human and animal models. Environmental Health Perspectives. 108(3), 511–533. doi:10.2307/3454543. JSTOR 3454543. PMC 1637807. PMID 10852851.
56. Newland M.C., Reed M.N., Rasmussen E., 2015. A hypothesis about how early developmental methylmercury exposure disrupts behavior in adulthood. BehaviouralProcesses. 114, 41–51. doi:10.1016/j.beproc.2015.03.007. PMC 4407818. PMID 25795099.
57.  Hursh J.B., Clarkson T.W., Miles E., Goldsmith L.A., 1989. Percutaneous absorption of mercury vapor by man. Arch. Environ. Health. 44(2), 120–127. doi:10.1080/00039896.1989.9934385. PMID 2494955.
58. Cherian M.G., Hursh J.G., Clarkson, T.W., 1978. Radioactive mercury distribution in biological fluids and excretion in human subjects after inhalation of mercury vapor. Archives of Environmental Health. 33, 190–214.
59. Kawamura H., 2017. The relation between law and technology in Japan: liability for technology-related mass damage in the cases of Minamata disease, asbestos, and the Fukushima Daiichi nuclear disaster. Contemporary Japan. 30(1), 3–27. doi:10.1080/18692729.2018.1423459.
60. Williams C., 1998 Environmental Victims: New Risks new Injustice. London Earthscan.
61. George Timothy S., 2001. Minamata: Pollution and the Struggle for Democracy in Postwar Japan. Harvard University Asia Center. ISBN 0-674-00785-9.
62.  Hilt B., Svendson K., Syverson T., Qvenild T., Sletvold H., Melo I., 2009. A review of mercury exposure and health of dental personnel. Neurotoxicology. 3, 1202-6.
63.  Svendsen K., Syversen T., Melø I., Hilt B.,2010. Pregnancy outcomes among female dental personnel – a registry-based retrospective cohort study. Scandian Journal of Work and Environmental Health. 36, 231-41.
64. Mutter J., Curth A., Naumann J., Deth R., Walach H., 2010. Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism. Journal of Alzheimer’s Disease. 22,  357–374.
65. Biornberg K.A., Vahter M., Berglund B., Niklasson B., Blennow M., Sandborgh G., 2005. Transport of methylmercury and inorganic mercury to the fetus and breast-fed infant.Environmental Health Perspectives. 113, 1381–1385.
66. Berglund M., Lind B., Bjornberg K.A., Palm B., Einarsson O., Vahter M., 2005.Methylmercury, Amalgams, and Children’s Health: Björnberg et al. Respond. Environmental Health. 4, 20-35.
67. Ellingsen D.G., Efskind J., Haug E., Thomassen Y., Martinsen I., Gaarder P.I., 2000. Journal of Applied Toxicology. 20, 483–489.
68. Rao M.V., Sharma P.S.N., 2001. Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice. Reproductive Toxicology. 15, 705–712.

69. Tanigawa T., Takehashi H., Nakata A., 2004. Naïve (CD4+CD45RA+) T Cell Subpopulation is Susceptible to Various Types of Hazardous Substances in the Workplace

 International journal of immunopathology and pharmacology. 17, 109–114.
70. Kosan C., Topaloglu A.K., Ozkan B., 2001. Dental Materials and Health: Including a Summary in English and an Overview .  Pediatrics International. 43, 429–430.
71. Siblerud R.L., Motl J., KienholzE., 1994. Psychometric evidence that mercury from silver dental fillings may be an etiological factor in depression, excessive anger, and anxiety. Psychological Reports. 74, 67–80.
72. Salonen J.T., Seppanen K., Nyyssonen K., 1995. Intake of Mercury From Fish, Lipid Peroxidation, and the Risk of Myocardial Infarction and Coronary, Cardiovascular, and Any Death in Eastern Finnish Men. Circulation. 91, 645–655.
73. Chan H.M., Egeland G.M., 2004. Fish consumption, mercury exposure, and heart diseases.Nutrition Reviews. 62, 68–72.
74.Brown P.,1995. Race, Class, and Environmental Health: A Review and Systematization of the Literature. Reviews on Environmental Health. 30, 4-10. 
75. Ramirez G.B., Pagulayan O., Akagi H., 2003. Pediatrics. Tagum Study II: Follow-up Study at Two Years of Age After Prenatal Exposure to Mercury. 111, 289–295.
76. Aitio A., Valkonen S., Kivisto H.E.,1983. Yrjanheikki, Effect of occupational mercury exposure on plasma lysosomal hydrolases.Inter Archiv Occup Environ Health. 53, 139–147.
77. Meyer-Baron M., Schaeper  M., Seeber A., 2002. A meta-analysis for neurobehavioural results due to occupational mercury exposure. Archives of Toxicology. 76, 127–136.
78. Rice D.C., 2004.The US EPA reference dose for methylmercury: sources of uncertainty. Environ Research. 95.  406–413.
79. Fujimura M., Usuki F., Sawada M., Takashima A.,2009. Methylmercury induces neuropathological changes with tau hyper phosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. NeuroToxicology. 30, 1000–1007.
80. Monnet-Tschudi F., Zurich M.,Boschat G.C., Corbaz, A., Honegger P., 2006.  Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev Environ Health. 21, 105–117.
81. British Dental Association (PDF). www.bda.org. March 2008. Retrieved 2016-01-27.
82. Use of dental amalgam in the UK : what do I need to know?. British Dental Association. 24 February 2016.
83.Booth S.,Zeller D., 2005. Mercury, Food Webs, and Marine Mammals: Implications of Diet and Climate Change for Human Health. Environmental Health Perspectives. 113, 521–526.
84. Dental Effluent Guidelines. Washington, D.C.: U.S. Environmental Protection Agency (EPA). 2017-07-07.
85. EPA (2017-06-14). "Effluent Limitations Guidelines and Standards for the Dental Category. Federal Register, 82 FR 27154.
Journal of Chemical Health Risks
Volume 12, Issue 2
May 2022
Pages 131-142

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History

  • Receive Date: 01 November 2019
  • Accept Date: 23 May 2020
  • First Publish Date: 01 May 2022

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