The Effect of ANGIPARS™ on Wound Healing in Patients with Diabetes: A Systematic Review

Document Type: Original Article

Authors

1 Assistant Professor of Vascular Surgery, clinical research development center of Imam Khomeini Hospital, Ilam University of Medical Science, Ilam, Iran

2 Assistant Professor of Anesthesiology, Department of Anesthesiology, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Department of Pharmacy, G. d'Annunzio University of Chieti-pescara, Chieti 66100, Italy

5 Student Research committee, kermanshah University of Medical Sciences, kermanshah, Iran

6 master of psychiatric nursing, Young Researchers Club, School of nursing, Islamic Azad University, Bandargaz Branch, Bandargaz, Iran

7 Student Research committee, Ilam University of Medical Sciences, Ilam, Iran

8 Zoonotic Disease Research Center, Ilam University of Medical Sciences, Ilam, Iran

9 Department of Nursing, Faculty of Nursing and Midwifery, kermanshah University of Medical Science, kermanshah, Iran

10.22034/jchr.2020.1890775.1090

Abstract

About 15% of patients with diabetes develop a Diabetic foot ulcer (DFU). It is an open sore or wound commonly located on the bottom of the foot.ANGIPARS™ is an Iranian-produced herbal remedy based on the extract of Melilotus officinalis. The aim of this study was to make a systematic review focused on determination of the effect of ANGIPARS™ on wound healing in patients with diabetes. The study was conducted in accordance with the PRISMA guidelines. Articles included in the review cover the period from the discovery of ANGIPARS™ to August 18, 2018. The data were analyzed using a descriptive method of Excel 2007 Software.Five articles with total number of 171 patients were included in the systematic review (SR) phase. In three articles, the methods were based on mm2 units and in the two others on cm2 units. Patients' follow-up varied from 4 weeks to 6 months after the intervention. In all patients, ANGIPARS™ responds well to the DFU disease. Due to the positive effect of the herbal drug, it is recommended to administer it for wound healing in patients with diabetes.

Keywords


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