Effect of Exercise Type and Adenosine on the Concentration of Lipoprotein Lipase, Triglyceride and Very Low Lipoprotein in High Fat Diets Fed Rats

Document Type: Original Article


Department of Sport Physiology, Damghan Branch, Islamic Azad University, Damghan, Iran


The effect of insulin-like adenosine in metabolism regulating, including glucose release and blood lipid metabolism, has been proven before. From one side, physical activity leads to Adenosine Monophosphate Protein Kinase (AMPK) activation and increasing (LPL) levels. Very light lipoprotein has the most combined affinity with the wall of the arteries, which leads to arteries occlusion. The purpose of the present study is to investigate the effect of two types of exercise (Endurance and Interval) and adenosine on the concentration of lipoprotein lipase, triglyceride and light lipoprotein in rats fed with high fat diets. In an experimental study, 70 male wistar rats were randomly divided into eight groups. In the first stage, subjects received high fat diet for 13 weeks. After that, they trained for 5 weeks each week for 12 weeks. At the end of the period, after the anesthetic, the heart and blood were removed to measure LPL, triglyceride (TG) and very low levels of lipoprotein (VLDL). High fat diet resulted in a significant increase in lipoprotein lipase, triglyceride and low valprooprotein levels. Intraperitoneal exercise showed a higher reduction in lipoprotein lipase compared with continuous exercise. Moreover, adenosine reduces lipoprotein lipase, and the interactive effect of adenosine and intolerant exercise was higher. Continuous exercise with adenosine had the greatest effect on reducing triglycerides. Regardless of its type, exercise with adenosine resulted in very low levels of lipoprotein levels. The effect of physical activity on the concentration of lipoprotein lipase, triglyceride and low lipoprotein is dependent on its type. Therefore, it is recommended that intensive periodic exercises with adenosine be used to protect the heart from damage caused by high fat diet.


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