Nano-TiO2 an Efficient, Clean and Eco-friendly Catalyst for Synthesis of Naphthoxazinone Derivatives as High Potent Antibacterial Agents

Document Type : Original Article


Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran


Oxazines naturally occurs and synthetically exhibit wide-ranging biological activity. In this study, a highly practical and efficient of 1,2-dihydro-1-phenylnaphtho[1,2-e][1,3]oxazine-3-one derivatives was developed via a multi-component reaction of 2-naphthol, aldehydes and urea in the presence of nano-titanium oxide as solid, recyclable catalyst at one-pot and solvent-free conditions. These synthetic compounds 2a-e were evaluated as potential antibacterial agents. The structures of products were confirmed by spectral analysis FT-IR and 1H NMR. The antibacterial activity of the compounds was screened against Staphylococcus aureus and Escherichia coli. These results showed that these compounds exhibited significant to moderate activities against both Gram (+) and Gram (-) organisms. 


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Volume 8, Issue 4
December 2018
Pages 305-312
  • Receive Date: 17 September 2016
  • Revise Date: 21 October 2016
  • Accept Date: 19 November 2016
  • First Publish Date: 01 December 2018