Dadar, H., Bzorgyan, R., Rahdan, F., Piraei, E., Edalatpanah, Y. (2017). Supplemental Effect of Zinc Oxide Nanoparticles and Prangos ferulacea Butanol Extract on Blood Glucose of Diabetic Wistar Rats. Journal of Chemical Health Risks, 7(2), -. doi: 10.22034/jchr.2017.544175
Hamid Dadar; Reza Bzorgyan; Freshteh Rahdan; Elahe Piraei; Yadollah Edalatpanah. "Supplemental Effect of Zinc Oxide Nanoparticles and Prangos ferulacea Butanol Extract on Blood Glucose of Diabetic Wistar Rats". Journal of Chemical Health Risks, 7, 2, 2017, -. doi: 10.22034/jchr.2017.544175
Dadar, H., Bzorgyan, R., Rahdan, F., Piraei, E., Edalatpanah, Y. (2017). 'Supplemental Effect of Zinc Oxide Nanoparticles and Prangos ferulacea Butanol Extract on Blood Glucose of Diabetic Wistar Rats', Journal of Chemical Health Risks, 7(2), pp. -. doi: 10.22034/jchr.2017.544175
Dadar, H., Bzorgyan, R., Rahdan, F., Piraei, E., Edalatpanah, Y. Supplemental Effect of Zinc Oxide Nanoparticles and Prangos ferulacea Butanol Extract on Blood Glucose of Diabetic Wistar Rats. Journal of Chemical Health Risks, 2017; 7(2): -. doi: 10.22034/jchr.2017.544175
Supplemental Effect of Zinc Oxide Nanoparticles and Prangos ferulacea Butanol Extract on Blood Glucose of Diabetic Wistar Rats
1Deptartment of Biochemistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2Deptartment of Microbiology, Shiraz Branch, Islamic Azad University Shiraz, Iran
3Deptartment of Biotechnology, Dehdasht Branch, Islamic Azad University, Dehdasht, Iran
4Deptartment of Biochemistry, Dehdasht Branch, Islamic Azad University, Dehdasht, Iran
Receive Date: 26 April 2017,
Revise Date: 11 December 2019,
Accept Date: 29 October 2018
Abstract
Diabetes mellitus is one of the most common diseases affecting the endocrine system. The prevalence of diabetes mellitus will be increasing in the human population. It is a metabolic disease characterized by chronic escalation of blood glucose and disrupted metabolism of carbohydrates, fats and proteins. This was an experimental study conducted on 40 male Wistar rats. This study was carried out in 2015 at the Islamic Azad University of Dehdasht. Diabetes was induced in the animals through Streptozotocin (STZ). After three days, blood glucose levels were measured. The rats were diagnosed with diabetes when blood glucose was more than 250. The data were analyzed through SPSS 21. Moreover, the independent t-test was used to examine the relationship between variables. Results of statistical analysis in relation to body weight of rats showed that there was a significant relationship between all groups at P<0.05 except for diabetic group and diabetic group by Prangos ferulacea Butanol extract as well as diabetic group by P. ferulacea butanol extract and diabetic groups by P. ferulacea butanol extract and zinc oxide nanoparticles. Concerning the glucose levels, there was a significant relationship between all groups at P<0.05. When applied as a supplement, zinc oxide nanoparticles and P. ferulacea butanol extract can have anti-diabetic properties, curtailing blood glucose, revealing that nanoparticles can be used in the future as a treatment for diabetes.
Bogunia-Kubik K., Sugisaka M., 2002. From molecular biology to nanotechnology and nanomedicine. Biosystems. 65, 123âââ138.
Gref R., Luck M., Quellec P., Marchand M., Del-lacherie E., Harnisch S., Blunk T., Muller, R. H. ,2000. ââÅStealthââ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. B Biointerfaces. 18, 301âââ313.
Shapiro K., Gong W.C., 2002. Natural products used for diabetes. J Am Pharm Assoc. 42(2), 217-226.
Soltani Kh., Kafash Farkhad N., Farokhi F., Tog-mechi A., 2012. Effects of hydro-alcoholic extract of Prangos ferulacea L. Lindle on histopathology of pancreas and diabetes treatment in STZ- induced diabetic rats. Avicenna Journal of Phytomedicine. 21, 31-38.
Moore A., Weissleder R., Bogdanov Jr., 1997. Up-take of dextrancoated monocrystalline iron oxides in tumor cells and macrophages. J Magn Reson Imaging. 7, 1140âââ1145.
Jadidoleslame M., SHahraki M., Abbasnejad M., 2011. The survey of Aleovera aqueous extra and glibenclamid interaction on blood glucose, LFT and lipids diabetic induced male rats by streptozotocin. Rafsanjan Med Univ J. 93, 185-194. (In Persian).
Srivastava Y., Venkatakrishnan-Bhatt H., Verma Y., 2003. Antidiabetic and adaptogenic properties of Momordica charantia extract: an experimental and clinical evaluation. Phytother Res.7, 285-289.
Coruh N., Celep A.G.S., Ozgokce F., 2007. Antioxi-dant properties of Prangos ferulacea L. Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. From Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase. Food Chem. 100(3), 1237-42.
Ghahraman A., 1985. Botany. Tehran University Press, Sixth Edition. pp. 201-189
Asadi-Samani M., Rafieian-Kopaei M., Azimi N., 2013. Gundelia: A systematic review of medicinal and molecular perspective. Pak J Biol Sci. 16(21), 1238-47.
Akhlaghi M., Shabanian G., Rafieian-Kopaei M., Parvin N., Saadat M., Akhlaghi M., 2011. Citrus au-rantium blossom and preoperative anxiety. Rev Bras Anestesiol. 61(6), 702-12.
Jafarzadeh L., Asgari A., Golshan-Iranpoor F., Kheiri S., Parvin N., Rafieian M., 2010. Abortificient effects of stachys lavandulifolia Vahl in mice. J Shahrekord Univ Med Sci. 11(4), 26-31.
Poole C.P.J., Owens F.J., 2003. Introduction to Nanotechnology. Hoboken Srivastava Y., Venkata-krishnan-Bhatt H., Verma Y., 2003. Antidiabetic and adaptogenic properties of Momordicacharantia ex-tract: an experimental and clinical evaluation. Phy-tother Res. 7, 285-289.
Burda C., Chen X., Narayanan R., El-Sayed M.A., 2005. Chemistry and properties of nanocrystals of different shapes. Chem Rev. 105, 1025-1102.
Mandade R., Sreenivas S.A., 2011. Anti-diabetic effect of aqueous ethanolic extract of Hibiscus rosasinesis L. on streptozotocin induced diabetic rats and the possible morphologic changes in the liver and kidney. Int J Pharm. 73, 363-369.
Kafash-Farkhad N., Farokhi F., Togmachi A., Soltani-band K., 2012. Hydro-alcoholic extract of the Root of Prangos ferulacea Lindle can improve serum glucose and lipids in alloxan induced diabetic rats. Avicenna J Phytomed. 2(4), 1-9.
Farokhi F., Kafash-farkhad N., Asadi-Samani M., 2013. Preventive effects of hydro-alcoholic extract of Prangos ferulacea L. Lindl. on kidney damages of diabetic rats induced by alloxan. J Shahrekord Univ Med Sci. 14(6), 72-81.
Zare T., Mokhtari M., Mohammadi J., 2012. The Effect of Hydroalcoholic Extracts of Prangos feru-lacea on Blood Factors of Kidney and Liver Functions in Diabetic Male Wistar Rats. JFUMS. 2(3), 174-180
Mahdavirad M., Najafzadeh N., Ali Niapour A., Jafari A., 2014. Cytotoxicity of Zno and Ag/Znonano-composites on malignant melanoma cell line, Arak Medical University Journal (AMUJ) Original Article. 17(87), 74-83
Heydarnejad M.S., Najafi M., Mobini- Dehkordi M., Rahnama S., 2014. An assessment of acute oral toxicity of ZnO nanoparticles on serum biochemical function of liver in mice. J Shahrekord Univ Med Sci. 16(1), 65-71.
Tripathi B.K., Srivastava A.K., 2006. Diabetes mellitus: complications and therapeutics. Med Sci Monit. 12(7), 130-47.
Roselli M., Finamore A., Garaguso I., Britti M.S., Mengheri E., 2003. Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli. J Nutr. 133(12), 4077- 82.
Kazerooni T., Mousavizade K., Abdollahee A., Sarkarian M., Sattar A., 2006. Aborifacient effect of Prangos ferulacea on pregnant rats. Contraception. 73(5), 554 - 6.
Top