Anti-Quorum Sensing Potential of Potato Rhizospheric Bacteria


1 Department of Plant Protection, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran

2 Department of Plant Protection, College of Agriculture and Natural Resources, University of Tehran, Karaj,

3 Department of Plant Protection, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran Transgenesis Center of Excellence, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan

4 Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran


The occurrence of antibiotic-resistant pathogenic bacteria is becoming a serious problem. The rise of multiresistance strains has forced the pharmaceutical industry to come up with new generation of more effective and potent antibiotics, therefore creating development of antivirulence compounds. Due to extensive usage of cell-to-cell bacterial communication (QS) systems to monitor the production of virulence factors, disruption of QS system results in creation of a promising strategy for the control of bacterial infection. Numerous natural quorum quenching (QQ) agents have been identified. In addition, many microorganisms are capable of producing smaller molecular QS inhibitors and/or macromolecular QQ enzymes. In present survey, anti QS activity of 1280 rhizosphere bacteria was assessed using the Pectobacterium carotovorum as AHL-donor and Chromobacterium violaceum CV026 as biosensor system. The results showed that 61 strains had highly AHL-degrading activity. Both Lux I and Lux R activity were affected by some isolates, suggesting that the rhizobacteria target both QS signal and receptor. These soil microorganisms with their anti-QS activity have the potential to be novel therapeutic agents for reducing virulence and pathogenicity of antibiotic resistant bacteria.


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Volume 7, Issue 1 - Serial Number 1
January 2017
Pages 39-47
  • Receive Date: 01 January 2017
  • Revise Date: 07 December 2019
  • Accept Date: 29 October 2018
  • First Publish Date: 29 October 2018