Response of Leptin and C-reactive Protein Serum Levels to 12 Weeks Moderate Intensity Aerobic Exercise in Obese Men

Authors

1 Department of Exercise Physiology, Faculty of Physical Education, University of Urmia, Urmia, Iran

2 Department of Physiology, Urmia University of Medical Science, Urmia, Iran

Abstract

The aim of this study was to investigate the effect of 12 weeks moderate intensity aerobic exercise on leptin and C-reactive protein serum levels in obese men. The study was conducted in Urmia- Iran in 2015. Twenty-four obese men with an aged range 40-50 yrs. were enrolled into the study. Subjects were randomized to one of 2 groups exercise (n=12) and control groups (n=12). The exercise group performed aerobic exercise training up to 50-70 % heart rate reserve, three times a week for 12 weeks. Leptin and CRP serum level was measured by ELISA method before and after the 12 weeks. After 12 weeks exercise training, leptin and CRP serum level in the exercise group compared to the control group, were decreased significantly (P<0.05). To sum up, 12 weeks moderate intensity aerobic exercise in the reduction of CRP and leptin concentration had a prominent role that might be effective in reducing weight and improving cardiovascular risk factors.

Keywords

References

1. Sasaki J.E., dos Santos M.G., 2006. The role of aerobic exercise on endothelial function and on cardiovascular risk factors. Arq Bras Cardiol. 87(5), 226-31.

2. Bhatt D.L., Steg P.G., Ohman E.M., Hirsch A.T., Ikeda Y., Mas J.L., Goto S., Liau C.S., Richard A.J., Röther J.,     Wilson P.W., 2006.  International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA. 295(2), 180-9.

3. Mogharnasi  M., Gaeini A., Sheikholeslami Vatani D., 2009. Comparing the effects of two training methods of aerobic and an aerobic on some pre-inflammatory cytokines in adult male rats. Ir J E Metabol. 11(2), 191-198.

4. Wilund K.R., 2007. Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease? Clinical Science. 112(11), 543-555.

5. Freeman D.J., Norrie J., Caslake M.J., Gaw A., Ford I., Lowe G.D., O'Reilly D.S., Packard C.J., Sattar N., 2002. C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes. 51(5), 1596-1600.

6. Selvin E., Paynter N.P., Erlinger T.P., 2007.The effect of weight loss on C-reactive protein - A systematic review. Archives of Internal Medicine. 167(1), 31-39.

7. Iikuni N., Lam QL., Lu L., Matarese G., La Cava A., 2008. Leptin and inflammation. Curr Immunol Rev. 4(2),70-79.

8. Kadoglou N.P., Iliadis F., Angelopoulou N., Perrea D., Ampatzidis G., Liapis C.D., Alevizos M., 2007. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil. 14(6), 837-43.

9. Loimaala A., Groundstroem K., Rinne M., Nenonen A., Huhtala H., Parkkari J., Vuori I., 2009. Effect of long term endurance and strength training on metabolic control and arterial elasticicty in patients with type2 diabetes mellitus. Am J Cardio. 103(7), 972-977.

10. Stewart L.K., Flynn M.G., Campbell W.W., Craig B.A., Robinson J.P., Timmerman K.L., McFarlin B.K., Coen P.M., Talbert E., 2007. The influence of exercise training on inflammatory cytokines and C-reactive protein. Medicine and Science in Sports and Exercise. 39(10), 1714-1719.

11. Ligibel J.A., Giobbie-Hurder A., Olenczuk D., Campbell N., Salinardi T., Winer E.P., Mantzoros C.S., 2009. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes Control. 20(8), 1523-8.

12. Bouhlel E., Denguezli M., Zaouali M., Tabka Z., Shephard R.J., 2008. Ramadan Fasting's Effect on Plasma Leptin, Adiponectin Concentrations, and Body Composition in Trained Young Men. International Journal of Sport Nutrition and Exercise Metabolism. 18(6), 617-627.

13. Nemoto K., Gen-no H., Masuki S., Okazaki K., Nose H., 2007. Effects of high-intensity interval walking training on physical fitness and blood pressure in middle-aged and older people. Mayo Clinic Proceedings. 82(7), 803-811.

14. Kamal N.N., Ragy M.M., 2012. The effects of exercise on C-reactive protein, insulin, leptin and some cardiometabolic risk factors in Egyptian children with or without metabolic syndrome. Diabetology & Metabolic Syndrome. 4(1), 4 -27.

15. Kraemer, R.R., H. Chu., V.D., 2002.Castracane, Leptin and exercise. Exp Biol Med (Maywood). 227(9), 701-8.

16.  Bouassida A.,  Zalleg D.,  Bouassida S., Zaouali M.,  Feki Y.,  Zbidi A., Tabka Z., 2006. Leptin, its implication in physical exercise and training: a short review. J Sports Sci Med. 5(2), 172-181.

17. Ning Y., Williams M.A., Butler C.L., Muy-Rivera M.,  Frederick I.O., Sorensen T.K., 2005.Maternal recreational physical activity is associated with plasma leptin concentrations in early pregnancy. Human Reproduction. 20(2), 382-389.

18. Dryden S., Frankish H., Wang Q., Williams G., 1994. Neuropeptide Y and energy balance: one way ahead for the treatment of obesity? Eur J Clin Invest. 24(5), 293-308.

19. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., 1996. Serum immunoreactive leptin concentrations in normal-weight and obese humans. New England Journal of Medicine. 334(5), 292-295.

 

Journal of Chemical Health Risks

Volume 7, Issue 1
Winter 2017
Pages 33-37

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History

  • Receive Date: 01 January 2017
  • Revise Date: 07 December 2019
  • Accept Date: 29 October 2018

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