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Rahimnejad, S., Bikhof Torbati, M. (2016). Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7. Journal of Chemical Health Risks, 6(3), -. doi: 10.22034/jchr.2016.544148
Sara Rahimnejad; Maryam Bikhof Torbati. "Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7". Journal of Chemical Health Risks, 6, 3, 2016, -. doi: 10.22034/jchr.2016.544148
Rahimnejad, S., Bikhof Torbati, M. (2016). 'Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7', Journal of Chemical Health Risks, 6(3), pp. -. doi: 10.22034/jchr.2016.544148
Rahimnejad, S., Bikhof Torbati, M. Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7. Journal of Chemical Health Risks, 2016; 6(3): -. doi: 10.22034/jchr.2016.544148

Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7

Article 6, Volume 6, Issue 3, Spring 2016  XML PDF (500.31 K)
DOI: 10.22034/jchr.2016.544148
Authors
Sara Rahimnejad email 1; Maryam Bikhof Torbati2
1Department of Chemistry, College of Basic science, Yadegar-e-Imam Khomeini (RAH( Shahre Rey Branch, Islamic Azad University, Tehran, Iran
2Department of Biology, College of Basic Science, Yadegar-e-Imam Khomeini(RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran
Receive Date: 06 June 2016,  Revise Date: 11 December 2019,  Accept Date: 29 October 2018 
Abstract
In this research, TiO2 nanotubes were synthesized by anodized oxidation method and were covered with a hydroxyapatite-silver nanoparticles using photodeposition and dip coating for loading silver nanoparticles and coated hydroxyapatite (HA). The morphological texture of TiO2 nanotube and Ag-HA nanoparticles on TiO2 nanotubes surface were studied by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDAX analysis) and X-ray diffraction (XRD). The MCF-7 cell lines were treated with concentrations 1, 10 and 100 µg/ml of TiO2 nanotubes and HA/Ag/TiO2 nanotube for 24 and 48h. Finally, the cell viability and IC50% were evaluated using MTT assay. The results show that the HA/Ag/TiO2 has more positive effect on enhancing the cell death compare to TiO2 nanotubes and also exerts a time and concentration-dependent inhibition effect on viability of MCF-7 cells
Keywords
hydroxyapatite; Nanotube; TiO2; anticancer; breast cancer; MCF-7
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