Biological Activity and Efficient Synthesis of 3, 4-Dihydropyrimidin-2-(1H)-one/thione Derivatives

Author

Department of Chemistry, Faculty of Science, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran

Abstract

The present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1H) - ones/thiones. The study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. To find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1H)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solvent-free conditions by using SiO2-CaCl2as acatalyst. Using this catalyst has some advantages; it's high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. The structural features of the synthesized compounds were characterized by IR, 1H NMR and 13C NMR. The compounds were screened for antimicrobial activity. The results showed these compounds react against all the tested bacteria. We have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by SiO2-CaCl2 under solvent-free conditions.

Keywords

References

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History

  • Receive Date: 30 November 2014
  • Revise Date: 29 November 2021
  • Accept Date: 29 October 2018

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