Aflatoxin M1 Contamination in Milk and Milk Products in Iran: A Review

Authors

Department of Microbiology, Faculty of Science, Lahijan Branch, Islamic Azad University, Lahijan, Iran

Abstract

Mycotoxins are secondary metabolites of molds and have adverse effects on humans, animals, and crops. Those can cause illnesses and economic losses. Aflatoxin M1 (AFM1) is one of the mycotoxins produced from the hydroxylated metabolite of aflatoxin B1 (AFB1). It can be found in milk or milk products obtained from livestock that have ingested contaminated feed. In this paper, recent studies were reviewed in aflatoxin M1 contamination in milk and milk products in Iran.

Keywords


  1. Tabari M., Tabari K., Tabari O. Occurrence of
  2. Aflatoxin M1 in Pasteurized Doogh
  3. Commercialized in Tehran, Iran. Australian
  4. Journal of Basic and Applied Sciences, 2011.
  5. (12): 1734-1737.
  6. Tajkarimi M., Aliabadi-Sh F., Salah Nejad A.,
  7. Poursoltani H., Motallebi A.A., Mahdavi H.,
  8. Aflatoxin M1 contamination in winter and summer
  9. milk in 14 states in Iran. Food Control, 2008.19:
  10. -1036.
  11. Nilchian Z., Rahimi E., Aflatoxin M1 in
  12. Yoghurts, Cheese and Ice-Cream in Shahrekord-
  13. Iran. World Applied Sciences Journal, 2012. 19
  14. (5): 621-624.
  15. Khlangwiset P., Shephard G.S., Wu F.,
  16. Aflatoxins and growth impairment: A review.
  17. Critical Reviews in Toxicol, 2011. 41: 1-16.
  18. Azizollahi Aliabadi M., Issazadeh K., Kazemi
  19. Darsanaki R., Laleh Rokhi M., Amini A.
  20. ,Determination of Aflatoxin M 1Levels in White
  21. Cheese Samples by ELISA in Gilan Province,
  22. Iran. Global Veterinaria, 2012. 8 (7): 707-710.
  23. Celik T.H., Sarımehmetoglu B., Kuplulu O.,
  24. Aflatoxin M1 contamination in pasteurised milk.
  25. Veterinarski Arhiv, 2005.75: 57-65.
  26. Akkaya L., Birdane Y.O., Oguz H., Cemek M.,
  27. Occurrence of aflatoxin M1 in yogurt samples from
  28. afyonkarahisar, Turkey. Bull Vet Inst Pulawy,
  29. 50: 517-519.
  30. European Commission (EC), No 1881/2006 of
  31. December 2006 setting maximum levels for
  32. certain contaminants in foodstuffs. Off J Eur
  33. Union, 2006. 364; 5-24.
  34. Ghiasian S.A., Maghsood A.H., Neyestani T.R.,
  35. Mirhendi S.H., Occurrence of aflatoxin M1 in raw
  36. milk during the summer and winter seasons in
  37. Hamedan, Iran. Journal of Food Safety, 2007. 27:
  38. ââ‚‌“198.
  39. Alborzi S., Pourabbas B., Rashidi M., Astaneh
  40. B., Aflatoxin M1 contamination in pasteurized
  41. milk in Shiraz (south of Iran). Food Control,
  42. 17(7): 582-584.
  43. Mokhtarian Dalouei H., Mohsenzadeh M.,
  44. Evaluation of Aflatoxin M1 in Pasteurized Milk
  45. Gonabad city. Ofogh-E-Danesh, 2005. 11(3): 5-9.
  46. Gholampour Azizi I., Khoushnevis S.H.,
  47. Hashemi S.J., Aflatoxin M1 level in pasteurized
  48. and sterilized milk of Babol city. Tehran
  49. University Medical Journal, 2007. 65: 20-24.
  50. Nazari A., Noroozi H., Movahedi M.,
  51. Khaksarian M., Measurement of Aflatoxin M1 in
  52. Raw and Pasteurized.Yafte, 2007. 9(3): 49-57.
  53. Tajik H., Razavi Rohani S.M., Moradi M.,
  54. Detection of Aflatoxin M1 in Raw and
  55. Commercial Pasteurized Milk in Urmia, Iran.
  56. Pakistan Journal of Biological Sciences, 2007.10:
  57. -4107.
  58. Sefidgar S.A.A., Mirzae M., Assmar M.,
  59. Naddaf S.R., Aflatoxin M1 in Pasteurized Milk in
  60. Babol city, Mazandaran Province, Iran. Iranian J
  61. Publ Health, 2011. 40:115-118.
  62. Karimi G., Hassanzadeh M., Teimuri M.,
  63. Nazari F., Nili A., Aflatoxin M1 Contamination in
  64. Pasteurized Milk in Mashhad, Iran. Iranian Journal
  65. of Pharmaceutical Sciences, 2007. 3(3): 153-156.
  66. Sefidgar S.A., Azizi G., Khosravi A.R.,
  67. Roudbar-Mohammadi S., Presence of Aflatoxin
  68. M1 in raw Milk at Cattle Farms in Babol, Iran.
  69. Pakistan Journal of Biological Sciences, 2008.
  70. (3):484-486.
  71. Mohammadian B., Khezri M., Ghasemipour
  72. N., Mafakheri Sh., Poorghafour Langroudi P.,
  73. Aflatoxin M1 contamination of raw and
  74. pasteurized milk produced in Sanandaj, Iran.
  75. Archives of Razi Institute, 2010. 65(2): 99-104.
  76. Kamkar A., Detection of aflatoxin M1 in
  77. powdered milk samples by ELISA. Pajouhesh &
  78. Sazandegi, 2007. 79: 174-180.
  79. Oveisi M.R., Jannat B., Sadeghi N.,
  80. Hajimahmoodi M., Nikzad A., Presence of
  81. aflatoxin M1 in milk and infant milk products in
  82. Tehran, Iran. Food Control, 2007.18: 1216ââ‚‌“1218.
  83. Movassagh M.H., Presence of aflatoxin in
  84. UHT milk in Tabriz (Northwest of Iran). Journal
  85. of Food Safety, 2011. 31(2): 238ââ‚‌“241.
  86. Mohamadi Sani A., Nikpooyan H., Moshiri R.,
  87. Aflatoxin M 1 contamination and antibiotic
  88. residue in milk in Khorasan province, Iran. Food
  89. and Chemical Toxicology, 2010. 48(8): 2130-
  90. Riazipour M., Tavakkoli H.R., Razzaghi
  91. Abyane M., Rafati H., Sadr Momtaz S.M.,
  92. Measuring the amount of M1 Aflatoxin in
  93. pasteurized milks. Kowsar Medical Journal, 2010.
  94. (2): 89-93.
  95. Fallah A.A., Aflatoxin M1 contamination in
  96. dairy products marketed in Iran during winter and
  97. summer. Food Control, 2010. 21: 1478-1481.
  98. Movassagh M.H., Presence of Aflatoxin M1
  99. Eweââ‚‌™s Milk in the Northwest Region of Iran.
  100. Journal of Applied Biological Sciences, 2009.
  101. (3):17-19.
  102. Behfar A., Nazari Khorasgani Z., Alemzadeh
  103. Z., Gudarzi M., Ebrahimi R., Tarhani N.,
  104. Determination of Aflatoxin M1 Levels in
  105. Produced Pasteurized Milk in Ahvaz City by
  106. Using HPLC. Jundishapur J Nat Pharm Prod,
  107. 7(2):80-84.
  108. Behnamipour S., Arast Y., Mohammadian M.,
  109. Occurence of aflatoxin M1 in two dairy products
  110. by ELISA in central part of Iran. Life Science
  111. Journal, 2012. 9(3): 1831-1833.
  112. Fallah A., Assessment of aflatoxin M1
  113. contamination in pasteurized and UHT milk
  114. marketed in central part of Iran. Food and
  115. Chemical Toxicology, Food Chem Toxicol, 2010.
  116. (3): 988-991.
  117. Daraei Garmakhany A., Zighamian H.,
  118. Sarhangpour R., Rasti M., Aghajani N.,
  119. Occurrence of Aflatoxin M1 in Raw and
  120. pasteurized milk in Esfahan province of Iran.
  121. Minerva Biotecnologica, 2011. 23: 53-7.
  122. Kamkar A., Jahed Khaniki G.R., Alavi S.A.,
  123. Occurrence of aflatoxin M1 in raw milk produced
  124. in Ardebil of Iran. Iran. J. Environ. Health. Sci.
  125. Eng, 2011. 8(2): 123-128.
  126. Kamkar A., The study of aflatoxin M1 in UHT
  127. milk samples by ELISA. J.Vet.Res, 2008. 63(2): 7-
  128. Sadeghi E., Almasi A., Bohloli-Oskoii S.,
  129. Mohamadi M., The Evaluation of Aflatoxin
  130. M1Level in Collected Raw Milk for Pasteurized
  131. Dairy. Zahedan J Res Med Sci, 2013. 15(3): 26-29.
  132. Rahimi E., Nilchian Z., Behzadnia A.,
  133. Presence of Aflatoxin M1 in Pasteurized and UHT
  134. Milk Commercialized in Shiraz, Khuzestan and
  135. Yazd, Iran. Journal of Chemical Health Risks,
  136. 1(1): 7-10.
  137. Panahi P., Kasaee S., Mokhtari A., Sharifi A.,
  138. Jangjou A., Assessment of Aflatoxin
  139. M1Contamination in Raw Milk by ELISA in
  140. Urmia, Iran. American-Eurasian Journal of
  141. Toxicological Sciences, 2011. 3(4): 231-233.
  142. Journal of Chemical Health Risks 3(3): 13-20, 2013
  143. ISSN:2251-6719
  144. Rahimi E., Mohammadhosseini M., Alimoradi
  145. M., Rezaei P., Arab M., Goudarzi M.A., Tarkesh
  146. Esfahani M., Torki Z., Aflatoxin M1 in
  147. Pasteurized Milk and White Cheese in Ahvaz,
  148. Iran. Global Veterinaria, 2012. 9(4): 384-387.
  149. Mohamadi Sani A., Khezri M., Moradnia H.,
  150. Determination of AflatoxinM1 in Milk by ELISA
  151. Technique in Mashad (Northeast of Iran). ISRN
  152. Toxicology, 2012.1-4.
  153. Gholi pour M., Karim zadeh L., Ali Nia F.,
  154. Babaee Z., Determination of Aflatoxin M1 in
  155. Mazandaran Province at the First Half of 1390. J
  156. Mazand Univ Med Sci, 2012. 22(93): 40-46.
  157. Laleh rokhi M., Kazemi Darsanaki R.,
  158. Mohammadi M., Hassani Kolavani M., Issazadeh
  159. K., Azizollahi Aliabadi M., Determination of
  160. Aflatoxin M1 Levels in Raw Milk Samples in
  161. Gilan, Iran. Advanced Studies in Biology, 2013. 5:
  162. -156.
  163. Mohamadi Sani A., Nikpoyan H.,
  164. Determination of aflatoxin M1 in milk by highperformance
  165. liquid chromatography in Mashhad
  166. (north east of Iran). Toxicol Ind Health, 2013.
  167. (4): 334-338.
  168. Fallah A.A., jafari T., Fallah A., Rahnama M.,
  169. Determination of aflatoxin Ml levels in Iranian
  170. white and cream cheese. Food and Chemical
  171. Toxicology, 2009. 47: 1872-1875.
  172. Rahimi E., Jafarian Dehkordi M., Iranpoor A.,
  173. A Survey of Aflatoxin M1 Contamination in
  174. Iranian White Cheese. Food Technology &
  175. Nutrition, 2011. 8(4): 51-56.
  176. Rahimi E., Mohammadhosseini M., Alimoradi
  177. M., Rezaei P., Arab M., Goudarzi M.A., Tarkesh
  178. Esfahani M., Torki Z., Aflatoxin M1 in
  179. Pasteurized Milk and White Cheese in Ahvaz,
  180. Iran. Global Veterinaria, 2012. 9(4): 384-387.
  181. RahimiE., Survey of the occurrence of
  182. aflatoxin M1 in dairy products marketed in Iran.
  183. Toxicol Ind Health, 2012. doi:
  184. 1177/0748233712462476.
  185. Akrami Mohajeri F., Ghalebi S.R., Rezaeian
  186. M., Gheisari H.R., Khorramdel Azad H.,
  187. Zolfaghari A., Fallah A., Aflatoxin M1
  188. contamination in white and Lighvan cheese
  189. marketed in Rafsanjan, Iran. Food Control, 2013.
  190. :525-527.
  191. Barjesteh M.H., Gholampour I., Noshfar E.,
  192. Occurrence of aflatoxin M1 in pasteurized and
  193. local yogurt in mazandaran province (Northern of
  194. Iran) using ELISA. Global Veterinaria, 2010. 4(5):
  195. -462.
  196. Issazadeh K., kazemi Darsanaki R., Majid
  197. Khoshkholgh Pahlaviani M. R., Occurrence of
  198. aflatoxin M1 levels in local yogurt samples in
  199. Gilan Province, Iran. Annals of Biological
  200. Research, 2012. 3 (8): 3853-3855.
  201. Tabari M., Tabari K., Tabari O., Aflatoxin M1
  202. determination in yoghurt produced in Guilan
  203. province of Iran using immunoaffinity column and
  204. high-performance liquid chromatography. Toxicol
  205. Ind Health, 2013. 29(1):72-76.
  206. Kazemi Darsanaki R., Azizollahi Aliabadi M.,
  207. Mohammad Doost Chakoosari M., Aflatoxin M1
  208. Contamination in Ice-Cream. Journal of Chemical
  209. Health Risks, 2013. 3(1): 43-46.
  210. Khosravi A., Shokri H., Eshghi S., Darvishi S.,
  211. Global occurrence of aflatoxin M1 in milk with
  212. particular reference to Iran, Food Security. 2013.
  213. 1007/s12571-013-0281-9.
  214. Davoudi Y., Garedaghi Y., Survey on
  215. Contaminated Raw Milks with Aflatoxin M1 in
  216. the Sarab Region, Iran. Research Journal of
  217. Biological Sciences, 2011. 6: 89-91.
  218. Vagef R., Mahmoudi R., Occurrence of
  219. Aflatoxin M1 in raw and pasteurized milk
  220. produced in west region of Iran (during summer
  221. and winter). International Food Research Journal,
  222. 20(3): 1421-1425.
  223. Heshmati A., Occurrence of aflatoxin M1 in
  224. Iranian white cheese. JFST, 2010. 7(2):117-122.
  225. Hazhir M., Sanoubar Tahaiee N., Rashidi K.,
  226. Rezaie R., Shaykhi H., Determination of the
  227. amount of aflatoxin in milk samples delivered to
  228. Sanandaj pasteurized Milk Corporation. SJKU,
  229. ; 13(1): 44-50.
  230. Rahimi E., Karim G., Determination of AFM1
  231. in the Raw Milk Producing in Dairy Farms in
  232. Chahar-Mahal-Bakhtiari Province Using ELISA.
  233. JFST, 2008. 5(1): 51-58.
  234. Afshar P., Shokrzadeh M., Kalhori S., Babaee
  235. Z., Saeedi Saravi S.S., Occurrence of Ochratoxin
  236. A and Aflatoxin M1 in human breast milk in Sari,
  237. Iran. Food Control, 2013. 31: 525-529.
  238. Kamkar A., Yazdankhah S., Mohammadi
  239. Nafchi A., Mozaffari Nejad A., Aflatoxin M1 in
  240. raw cow and buffalo milk in Shush city of Iran.
  241. Food Additives & Contaminants: Part B, 2013.
  242. doi:10.1080/19393210.2013.830277.
  243. Tavakoli HR., Riazipour M., Rafati Shaldehi
  244. H., Shahriari M., Naghavi S., Rahmati Najarkolaei
  245. F., AFM1 Contamination in used yogurt in one
  246. the of universities of medical sciences in Tehran
  247. by ELISA. Quarterly of the Horizon of Medical
  248. Sciences, 2013. 5S: 261-268