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Elezaj, I., Letaj, K., Selimi, Q., Rrustemi, A., Zogaj, D., Sefaja, L. (2012). Blood Lead Level and Δ-Aminolevulinic Acid Dehydratase Activity in Pre-Menopausal and Postmenopausal Women. Journal of Chemical Health Risks, 2(2), -. doi: 10.22034/jchr.2012.543989
I.R Elezaj; K.Rr. Letaj; Q.I. Selimi; A. Rrustemi; D. Zogaj; L. Sefaja. "Blood Lead Level and Δ-Aminolevulinic Acid Dehydratase Activity in Pre-Menopausal and Postmenopausal Women". Journal of Chemical Health Risks, 2, 2, 2012, -. doi: 10.22034/jchr.2012.543989
Elezaj, I., Letaj, K., Selimi, Q., Rrustemi, A., Zogaj, D., Sefaja, L. (2012). 'Blood Lead Level and Δ-Aminolevulinic Acid Dehydratase Activity in Pre-Menopausal and Postmenopausal Women', Journal of Chemical Health Risks, 2(2), pp. -. doi: 10.22034/jchr.2012.543989
Elezaj, I., Letaj, K., Selimi, Q., Rrustemi, A., Zogaj, D., Sefaja, L. Blood Lead Level and Δ-Aminolevulinic Acid Dehydratase Activity in Pre-Menopausal and Postmenopausal Women. Journal of Chemical Health Risks, 2012; 2(2): -. doi: 10.22034/jchr.2012.543989

Blood Lead Level and Δ-Aminolevulinic Acid Dehydratase Activity in Pre-Menopausal and Postmenopausal Women

Article 1, Volume 2, Issue 2, Summer 2012  XML PDF (231.24 K)
DOI: 10.22034/jchr.2012.543989
Authors
I.R Elezaj 1; K.Rr. Letaj1; Q.I. Selimi1; A. Rrustemi1; D. Zogaj2; L. Sefaja2
1Department of Biology, University of Prishtina, Republic of Kosovo
2Institute of National Public Health, University of PrishtinaP.O.Box 10.000 Prishtinë, Republic of Kosovo
Receive Date: 12 July 2012,  Revise Date: 18 February 2019,  Accept Date: 29 October 2018 
Abstract
To describe the relationship of blood lead levels (BLL) and blood, δ-aminolevulinic acid dehydratase(ALAD) activity and haematocrit value(Hct) to menopause , were examined 17 pre-or perimenopausal (PreM) and 17 postmenopausal women (PosM)from Prishtina City, the capital ofRepublic Kosovo. The mean age of the PreM women was 28.8 years (21-46), with a mean blood lead level of 1.2 μg/dL (SD=0.583 μg/dL ) , the mean blood ALAD activity53.2 U/LE (SD= 2.8 U/LE) and haematocrit value42.1 % (SD= 4.3 %). The mean age of the PosM women was 53.6 years (43-67), with a mean blood lead level1.9 μg/dL (SD=0.94 μg/dL), the mean blood ALAD activity 44.4 U/LE(SD=7.2 U/LE) and haematocrit value 42.1 % ( SD= 4.3 %) and 42.2 % (SD=4.4 %). The BPb level of PosM women was significantly higher (P<0.001) in comparison with the BPb level in PreM women. The blood ALAD activity of PosM was significantly inhibited (P<0.002) in comparison with blood ALAD activity in PreM women. The haematocrit values were relatively unchanged. There was established significantly negative correlation between BPb and blood ALAD activity (r=- 0.605; P<0.01) in the PreM women.These results support the hypothesis that release of bone lead stores increases during menopause and constitutes an internal source of exposure possibly associated with adverse health effects on women in menopause transition.
Keywords
Women; Menopause; Blood; ALAD; Hct; Lead
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