Study of Stability and Dispersibility of Oxidized Multiwall Carbon Nanotube and Characterization with Analytical Methods for Bioapplication



Nanotechnology is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension size from 1 to 100 nanometers.  Carbon nanotubes have great potentials for novel applications in industry, drug delivery system and many other uses. In this work after purification, multiwall carbon nanotube was functionalized in acids by liquid phase oxidation method for drug delivery system. The structural and chemical changes after carboxylation of MWNTs improved the solubility and dispersibility of the carboxylated MWNTs in water. Fourier transformed infrared spectroscopy, and transmission electron microscopies were carried out for characterization of these methods of MWCNTs functionalization.


  1. Balasubramanian. K. and M. Burghard, 2004,Chemically Functionalized Carbon Nanotubes, small, Vol. 1,pp.180-192.
  2. Bianco A., K. Kostarelos and M. Prato, 2005,Applications of carbon nanotubes in drug delivery. Current Opinion in Chemical Biology,pp.674ââ‚‌“679.
  3. Biro L.P., ´N.Q. Khanh, Z. Ve´rtesy, Z.E. Horva´th, Z. Osva´th , A. Koo´s, J. Gyulai, A. Kocsonya, Z. Ko´nya, X.B. Zhang, G. Van Tendeloo, A. Fonseca and J.B. Nagy, 2002,Catalyst traces and other impurities in chemically purified carbon. Materials Science and Engineering,pp.9-13.
  4. Chung C.-L, K. Nguyen, S. Lyonnais, S. Streiff , S. Campidelli , L. Goux-Capes, J.-P Bourgoin , A.Filoramo,DNA Linked To Single-Wall Carbon Nanotubes: Covalent Versus Non-Covalent Approach. International Symposium on DNA-Based Nanodevices,pp.129-139.
  5. Datsyuka V., M. Kalyvaa, K. Papagelisb, J. Partheniosa, D. Tasisb, A. Siokoua, I. Kallitsisa and C. Galiotisa, 2008. Chemical oxidation of multiwalled carbon nanotubes. Carbonpp. 833ââ‚‌“840.
  6. Foldvari M. And M. Bagonluri, 2008,Carbon nanotubes as functional excipients for nanomedicines Nanomedicine: Nanotechnology, Biology, and Medicine,pp.173ââ‚‌“182.
  7. Future directions in Carbon Science. Dresselhaus M.S., 1997, Carbon Nanotubes: From Fundamental Nanoscale Objects Towards Functional Nanocomposites and Applications. Annu. Rev. Mater. Sci,pp.1ââ‚‌“34.
  8. Haipeng L., N. Zhao, H. Chunnian, Ch. Shi, X. Du, J. Li, 2008,Materials Science and Engineering,pp.355-359.
  9. Haipeng L., N. Zhaoa, Ch. Hea, Ch. Shi, X. Dua and J. Li, 2007. Thermogravimetric analysis and TEM characterization of the oxidation and defect sites of carbon nanotubes synthesized by CVD of methane, Materials Science and Engineering ,pp. 355-359
  10. Heisterveraneves E., S. Ravi P. Silva, Johnjoe McFadden and Helen M. Coley2011,Carbon Nanotubes Loaded with Anticancer Drugs: A Platform for Multimodal Cancer Treatment.Carbon Nanostructures,pp.223-245.
  11. Iijima S., 1991,Helical microtubules of graphitic carbon.Nature,pp.56 - 58.
  12. LiSaiJinXiao D. and Ch. Huang, 2010. A novel drug delivery system.,Pharmacia and biological functionalities of nutrient broth dispersed multi-walled carbon nanotubes SCIENCE CHINA Chemistry,Vol. 53,pp.612-618
  13. Liu J., G. Andrew Rinzler, D. Hongjie, H. Jason Hafner, R. Kelley Bradley, Peter J. Boul, A. Lu, T. Iverson, K. Shelimov, Ch. B. Huffman, F. Rodriguez-Macias, Y. S. Shon, T. Randall Lee, D. T. Colbert, R. E. Smalley, 1998. Fulleren pipe,science,vol 280.
  14. Martisa P., B. R. Venugopala, J. Delhallea and Z. Mekhalif, 2011,Selective decoration of nickel and nickel oxide nanocrystals on multiwalled carbon nanotubes. Journal of Solid State Chemistry,pp.1245-1250.
  15. Masera W., M. Benito, E. Muñoz and M. Teresa Martínez, 2008,Functionalized Nanoscale Materials,pp.101-119.
  16. Mohd A. Y., N. Ahmad Nizam and N. Aini Abd Rashid, 2010,Hydrothermal conversion of rice husk ash.porous mater,pp. 39ââ‚‌“47.
  17. Nirajandjohn T and W. Yeow, 2005,Carbon Nanotubes for Biomedical Applications.IEEE Transactions on Nanobioscience, Vol. 4,pp.180-195.
  18. Raymond .M, "Carbon Nanotubes: Potential Benefits and Risks of Nanotechnology in Nuclear Medicine." the journal of nuclear medicine 48 (2007): 1039-1042.
  19. Russier J., C. Ménard-Moyon, E. Venturelli, E. Gravel, G. Marcolongo, M. Meneghetti, E. Doris and A. Bianco, 2011,Oxidative biodegradation of single- and multi-walled carbon nanotubes. Thermogravimetric analysis and TEM characterization of the oxidation and defect sites of carbon nanotubes synthesized by CVD of methane.Nanoscale,pp.893ââ‚‌“896.
  20. Sim R. B., R. Klingeler, 2011. Carbon nanotubes for Biomedical applications, p 34, 132, 260
  21. Sungchul L., Zh. Zhanga, X. Wanga, L. D. Pfefferlea and G. L. Haller, 2011. Characterization of multi-walled carbon nanotubes catalyst supports by point of zero charge. Catalysis Today,Vol. 164,pp.68-73.
  22. Vivek S., M. Thakare, D. Anasmita, K. Amitjain, S. Patil and S. Jain, 2010,Carbon nanotubes in cancer theragnosis. Nanomedicine,pp.1277-1301.
  23. Wanga Sh., R. Liangb, B. Wangb and Ch. Zhang, 2008,Load-transfer in functionalized carbon nanotubes/polymer composites. Chemical Physics Letters,Vol. 457,pp.371-371
  24. Yang W., P. Thordarson, J. Justin Gooding, S. P Ringer and F. Braet, 2007,Carbon nanotubes for biological and biomedical applications. Nanotechnology, vol:18 .
  25. Zdenko Š., A. Christoforos, B. Krontiras, N. Stavroula and C. Galiotis, 2009,Effect of oxidation treatment of multiwalled carbon
  26. nanotubes on the mechanical and electrical properties of their epoxy composites. Applied Science and Manufacturing,Vol. 40,pp.778-783.
  27. Zhaowei W., M. D. Shirley, T. Steven, M. Raymond, L.D. Whitby and V. Sergey Mikhalovsky, 2009,The surface acidity of acid oxidised multi-walled carbon nanotubes and the influence of in-situ generated fulvic acids on their stability in aqueous dispersions. CARBON, pp.73 ââ‚‌“79