Goldouzian F., Momen-Heravi M. and Chamani J., G. (2012). The Investigation of the Interaction between Human Serum Transferring with Colchicine in the Presence of Pb+2 Ions: Synchronous Fluorescence Measurements. Journal of Chemical Health Risks, 1(2), -. doi: 10.22034/jchr.2012.543974
Goldouzian Z. Goldouzian F., Momen-Heravi M. and Chamani J.. "The Investigation of the Interaction between Human Serum Transferring with Colchicine in the Presence of Pb+2 Ions: Synchronous Fluorescence Measurements". Journal of Chemical Health Risks, 1, 2, 2012, -. doi: 10.22034/jchr.2012.543974
Goldouzian F., Momen-Heravi M. and Chamani J., G. (2012). 'The Investigation of the Interaction between Human Serum Transferring with Colchicine in the Presence of Pb+2 Ions: Synchronous Fluorescence Measurements', Journal of Chemical Health Risks, 1(2), pp. -. doi: 10.22034/jchr.2012.543974
Goldouzian F., Momen-Heravi M. and Chamani J., G. The Investigation of the Interaction between Human Serum Transferring with Colchicine in the Presence of Pb+2 Ions: Synchronous Fluorescence Measurements. Journal of Chemical Health Risks, 2012; 1(2): -. doi: 10.22034/jchr.2012.543974
The Investigation of the Interaction between Human Serum Transferring with Colchicine in the Presence of Pb+2 Ions: Synchronous Fluorescence Measurements
Receive Date: 30 January 2012,
Revise Date: 11 December 2019,
Accept Date: 29 October 2018
Abstract
The interaction between Holo-Transferin (HTF) and Colchicine (COL) was investigated in the present of Pb+2 ions under physiological conditions by using synchronous fluorescence spectra. The synchronous fluorescence spectra show a slight change of tryptophan residue micro-environment. Synchronous fluorescence spectra show that the structure of the tyrosine residue environment was altered by interaction of the COL and Pb+2 ions with HTF. The fluorescence intensity of HTF decreased regularly beside a small blue shift with increasing concentrations of COL and Pb+2 ions. The intrinsic fluorescence of HTF was quenched in the presence of drug and ion. Interaction of drugs with HTF and HTF-Pb+2 can elucidate the properties of drug-protein and ion- protein complex, as it may provide useful information about the structural feature that determines the therapeutic effectiveness of ion and drugs. Therefore, it has become a significant research field in life science, chemistry, biotechnology and clinical medicine.
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